EP 2374806 A1 20111012 - OXAZOLIDINON-QUINOLONE HYBRIDES AND INTERMEDIATES FOR THEIR PREPARATION
Title (en)
OXAZOLIDINON-QUINOLONE HYBRIDES AND INTERMEDIATES FOR THEIR PREPARATION
Title (de)
OXAZOLIDINON-CHINOLON HYBRIDE UND ZWISCHENPRODUKTE ZU DEREN HERSTELLUNG
Title (fr)
OXAZOLIDINON-QUINOLON HYBRIDES ET INTERMÉDIAIRES POUR LEUR PRÉPARATION
Publication
Application
Priority
- EP 04764810 A 20040903
- DE 10340485 A 20030903
Abstract (en)
Oxazolidinyl- or dihydrofuranyl-substituted fluoro-benzene or -pyridine derivatives (ZP) are new. Oxazolidinyl- or dihydrofuranyl-substituted fluoro-benzene or -pyridine derivatives of formula (ZP) are new. [Image] U : N or CH; V : O, S or CR 6>R 7>; W : (hetero)cycloalkylene, (hetero)alkylcycloalkylene, (hetero)arylene, (hetero)aralkylene (all optionally substituted), bond, O, S or NR 8>; X : O or S; Y : group of formula (a) - (f); Z : alkylene, alkenylene, alkynylene, heteroalkylene, (hetero)cycloalkylene, (hetero)alkylcycloalkylene, (hetero)arylene or (hetero)aralkylene (all optionally substituted); R 8> : hydrogen, (hetero)alkyl, alkenyl, alkynyl, (hetero)aryl, (hetero)cycloalkyl, (hetero)alkylcycloalkyl, aralkyl or heteroaralkyl; and R 6>, R 7> : hydrogen, (hetero)alkyl, alkenyl, alkynyl, (hetero)aryl, (hetero)cycloalkyl, (hetero)alkylcycloalkyl, aralkyl, heteroaralkyl, halo, hydroxy, amino, nitro or thiol. [Image] ACTIVITY : Antibacterial. No details of tests are given. MECHANISM OF ACTION : None given in the source material.
Abstract (de)
Die vorliegende Erfindung beschreibt Zwischenprodukte (ZP) für eine neue und effiziente Synthese von Verbindungen, bei denen die Pharmakophore von Chinolon und Oxazolidinon über einen chemisch stabilen Linker miteinander verknüpft sind.
IPC 8 full level
C07D 413/12 (2006.01); C07D 263/20 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR US)
A61P 31/00 (2017.12 - EP); C07D 263/20 (2013.01 - EP KR US); C07D 413/12 (2013.01 - EP KR US); C07D 413/14 (2013.01 - EP US); C07D 471/04 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP)
Citation (search report)
- [E] WO 2004096221 A1 20041111 - MORPHOCHEM AG KOMB CHEMIE [DE], et al
- [E] WO 2005058888 A2 20050630 - MORPHOCHEM AG [DE], et al
- [XP] US 2004132764 A1 20040708 - LOCHER HANS [CH]
- [XP] WO 2004069816 A1 20040819 - RANBAXY LAB LTD [IN], et al
- [XD] WO 03032962 A2 20030424 - MORPHOCHEM AG KOMB CHEMIE [DE], et al
- [X] WO 0146164 A1 20010628 - ORTHO MCNEIL PHARM INC [US]
- [X] WO 0109107 A1 20010208 - UPJOHN CO [US], et al
- [X] WO 0010566 A1 20000302 - BRISTOL MYERS SQUIBB CO [US]
- [XP] HUBSCHWERLEN CHRISTIAN ET AL: "Structure-activity relationship in the oxazolidinone-quinolone hybrid series: Influence of the central spacer on the antibacterial activity and the mode of action.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 23, 1 December 2003 (2003-12-01), pages 4229 - 4233, XP002308675, ISSN: 0960-894X
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005023801 A1 20050317; AU 2004270379 A1 20050317; AU 2004270379 B2 20110331; BR PI0414107 A 20070427; BR PI0414107 B1 20180703; BR PI0414107 B8 20210525; CA 2537345 A1 20050317; CA 2537345 C 20130129; CN 100467466 C 20090311; CN 1845923 A 20061011; DE 10340485 A1 20050512; DE 10340485 B4 20150513; EP 1660489 A1 20060531; EP 1660489 B1 20140702; EP 2374806 A1 20111012; EP 2374806 B1 20161102; ES 2509868 T3 20141020; HK 1083848 A1 20060714; IL 173407 A0 20060611; IL 205706 A0 20110801; IL 205706 A 20130627; JP 2007504262 A 20070301; JP 4742039 B2 20110810; KR 101211025 B1 20121211; KR 20060121849 A 20061129; MX PA06002366 A 20060620; NZ 545491 A 20091224; RU 2006110535 A 20071010; RU 2373203 C2 20091120; US 2007004769 A1 20070104; US 2009306389 A1 20091210; US 7557214 B2 20090707; US 8124772 B2 20120228; ZA 200601178 B 20070425
DOCDB simple family (application)
EP 2004009858 W 20040903; AU 2004270379 A 20040903; BR PI0414107 A 20040903; CA 2537345 A 20040903; CN 200480025284 A 20040903; DE 10340485 A 20030903; EP 04764810 A 20040903; EP 10011797 A 20040903; ES 04764810 T 20040903; HK 06106306 A 20060601; IL 17340706 A 20060129; IL 20570610 A 20100512; JP 2006525723 A 20040903; KR 20067004155 A 20060228; MX PA06002366 A 20040903; NZ 54549104 A 20040903; RU 2006110535 A 20040903; US 45581009 A 20090605; US 57077506 A 20060303; ZA 200601178 A 20040903