EP 2376061 A1 20111019 - AQUEOUS COACERVATE COMPOSITION COMPRISING POORLY WATER-SOLUBLE BIOLOGICALLY-ACTIVE AGENTS
Title (en)
AQUEOUS COACERVATE COMPOSITION COMPRISING POORLY WATER-SOLUBLE BIOLOGICALLY-ACTIVE AGENTS
Title (de)
WÄSSRIGE KOAZERVAT-ZUSAMMENSETZUNG AUS SCHWER WASSERLÖSLICHEN BIOLOGISCHEN WIRKSTOFFEN
Title (fr)
COMPOSITIONS AQUEUSES COACERVÉES COMPRENANT DES AGENTS BIOLOGIQUEMENT ACTIFS FAIBLEMENT SOLUBLES DANS L'EAU
Publication
Application
Priority
- EP 2010050330 W 20100113
- GB 0900473 A 20090113
Abstract (en)
[origin: WO2010081815A1] This invention relates to an aqueous gelatin-free, egg portion-free, two-phase coacervate composition comprising a coacervate phase and an equilibrium water phase, comprising, per 100 parts by weight, a mixture of: (a) from 2 to 30 parts by weight of a poorly water-soluble bio-active agent, (b) from 5 to 55 parts by weight of a polysaccharide-free tensio-active system with a HLB from 8 to 18 and consisting of non-ionic tensio-active agents, (c) from 2 to 40 parts by weight of one or more water-soluble carriers for said poorly water-soluble bio-active agent, said carriers being selected from the group consisting of maltodextrins with a molecular weight below 1,800, erythritol, xylitol, sorbitol, mannitol, maltitol, isomalt and lactitol, and (d) from 20 to 85 parts by weight of water, wherein the weight ratio (c)/(b) of the water-soluble carriers to the non-ionic tensio- active agents in the said mixture is from 0.005/1 to 3.5/1. Such coacervate compositions may be dried into solid dosage forms from which rapid release of the bio-active agent can be obtained.
IPC 8 full level
A61K 9/10 (2006.01); A61K 9/16 (2006.01); A61K 31/7048 (2006.01)
CPC (source: EP)
A61K 9/10 (2013.01); A61K 9/1694 (2013.01); A61K 31/00 (2013.01); A61K 31/155 (2013.01)
Citation (search report)
See references of WO 2010081815A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010081815 A1 20100722; EP 2376061 A1 20111019; GB 0900473 D0 20090211
DOCDB simple family (application)
EP 2010050330 W 20100113; EP 10702263 A 20100113; GB 0900473 A 20090113