Global Patent Index - EP 2377878 A1

EP 2377878 A1 20111019 - Potent compstatin analogs

Title (en)

Potent compstatin analogs

Title (de)

Potente Compstatin-Analoga

Title (fr)

Analogues puissants de la compstatine

Publication

EP 2377878 A1 20111019 (EN)

Application

EP 11001293 A 20061128

Priority

  • EP 06844589 A 20061128
  • US 74020505 P 20051128

Abstract (en)

Compounds comprising peptides and Peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds.

IPC 8 full level

A61K 38/08 (2006.01); A61K 38/16 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01)

CPC (source: CN EP RU US)

A61K 38/10 (2013.01 - RU); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP RU); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 1/00 (2013.01 - US); C07K 7/08 (2013.01 - CN EP RU US); C07K 7/64 (2013.01 - US); C07K 14/472 (2013.01 - EP US); A61K 38/00 (2013.01 - CN EP US)

Citation (applicant)

  • US 74020505 P 20051128
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  • US 4576750 A 19860318 - PITZENBERGER STEVEN M [US]
  • US 4299838 A 19811110 - DURLACH JEAN P
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Citation (search report)

  • [AD] WO 2004026328 A1 20040401 - UNIV PENNSYLVANIA [US], et al
  • [E] WO 2007044668 A2 20070419 - POTENTIA PHARMACEUTICALS INC [US], et al
  • [XPY] KATRAGADDA MADAN ET AL: "Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.", JOURNAL OF MEDICINAL CHEMISTRY 27 JUL 2006, vol. 49, no. 15, 27 July 2006 (2006-07-27), pages 4616 - 4622, XP002441762, ISSN: 0022-2623
  • [Y] DENNIS M S ET AL: "Albumin binding as a general strategy for improving the pharmacokinetics of proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC, US, vol. 277, no. 38, 20 September 2002 (2002-09-20), pages 35035 - 35043, XP002285300, ISSN: 0021-9258, DOI: 10.1074/JBC.M205854200
  • [Y] VERONESE F M: "Peptide and protein PEGylation - a review of problems and solutions", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 22, no. 5, 1 March 2001 (2001-03-01), pages 405 - 417, XP004227886, ISSN: 0142-9612, DOI: 10.1016/S0142-9612(00)00193-9

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2007062249 A2 20070531; WO 2007062249 A3 20070913; AU 2006318333 A1 20070531; BR PI0619023 A2 20110920; BR PI0619023 B1 20220927; CA 2631443 A1 20070531; CA 2631443 C 20170919; CA 2971349 A1 20070531; CA 2971349 C 20200908; CN 101400692 A 20090401; CN 101400692 B 20130102; CN 102977191 A 20130320; CN 102977191 B 20160810; CN 106188239 A 20161207; CN 106188239 B 20200107; DK 1960422 T3 20120813; EP 1960422 A2 20080827; EP 1960422 B1 20120530; EP 2377877 A1 20111019; EP 2377877 B1 20180328; EP 2377878 A1 20111019; EP 2377878 B1 20180328; EP 3363810 A1 20180822; ES 2390828 T3 20121116; ES 2677619 T3 20180803; ES 2677947 T3 20180807; HK 1124621 A1 20090717; HR P20120621 T1 20120930; IL 191674 A0 20090211; IL 191674 A 20150430; IL 237915 B 20181129; JP 2009517476 A 20090430; JP 2013177403 A 20130909; JP 5302004 B2 20131002; JP 5927139 B2 20160525; PL 1960422 T3 20121130; PT 1960422 E 20120816; RS 52429 B 20130228; RU 2008126232 A 20100110; RU 2012147267 A 20140520; RU 2474586 C2 20130210; RU 2656102 C2 20180531; US 2008227717 A1 20080918; US 2012004393 A1 20120105; US 2016096866 A1 20160407; US 2017305971 A1 20171026; US 2019016758 A1 20190117; US 7888323 B2 20110215; US 9169307 B2 20151027

DOCDB simple family (application)

US 2006045539 W 20061128; AU 2006318333 A 20061128; BR PI0619023 A 20061128; CA 2631443 A 20061128; CA 2971349 A 20061128; CN 200680051817 A 20061128; CN 201210455683 A 20061128; CN 201610550392 A 20061128; DK 06844589 T 20061128; EP 06844589 A 20061128; EP 11001292 A 20061128; EP 11001293 A 20061128; EP 18164436 A 20061128; ES 06844589 T 20061128; ES 11001292 T 20061128; ES 11001293 T 20061128; HK 09101849 A 20090226; HR P20120621 T 20120730; IL 19167408 A 20080522; IL 23791515 A 20150324; JP 2008543388 A 20061128; JP 2013090484 A 20130423; PL 06844589 T 20061128; PT 06844589 T 20061128; RS P20120353 A 20061128; RU 2008126232 A 20061128; RU 2012147267 A 20121106; US 201113007196 A 20110114; US 201514850686 A 20150910; US 201715490437 A 20170418; US 201815879978 A 20180125; US 60518206 A 20061128