EP 2380606 A1 20111026 - Methods of manufacturing and modifying taxane coatings for implantable medical devices

Title (en)

Methods of manufacturing and modifying taxane coatings for implantable medical devices

Title (de)

Verfahren zur Herstellung und Modifizierung von Taxanbeschichtungen für implantierbare medizinische Vorrichtungen

Title (fr)

Procédés de fabrication et de modification de revêtements de taxane pour dispositifs médicaux implantables

Publication

EP 2380606 A1 20111026 (EN)

Application

EP 11167978 A 20070628

Priority

EP 07810005 A 20070628
US 81817506 P 20060630
US 83072606 P 20060713
US 83066006 P 20060713

Abstract (en)

This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

IPC 8 full level

A61L 31/16 (2006.01)

CPC (source: EP)

A61L 31/16 (2013.01); A61L 2300/416 (2013.01); A61L 2300/606 (2013.01)

Citation (applicant)

US 6858644 B2 20050222 - BENIGNI DANIEL A [US], et al
EP 0717041 A1 19960619 - BRISTOL MYERS SQUIBB CO [US]
US 21312602 A 20020805
US 2004024448 A1 20040205 - CHANG JAMES W [US], et al
US 66287704 A
US 2004117007 A1 20040617 - WHITBOURNE RICHARD J [US], et al
WO 9407882 A1 19940414 - RHONE POULENC RORER SA [FR]
WO 9407881 A1 19940414 - RHONE POULENC RORER SA [FR]
WO 9407880 A1 19940414 - RHONE POULENC RORER SA [FR], et al
WO 9407876 A1 19940414 - RHONE POULENC RORER SA [FR], et al
WO 9323555 A1 19931125 - PENN STATE RES FOUND [US], et al
WO 9310076 A1 19930527 - UNIV MISSISSIPPI [US]
WO 9400156 A1 19940106 - ERBA CARLO SPA [IT]
WO 9324476 A1 19931209 - CLOVER CONS LTD [CH], et al
EP 0590267 A2 19940406 - BRISTOL MYERS SQUIBB CO [US]
WO 9420089 A1 19940915 - ENZON INC [US]
US 5294637 A 19940315 - CHEN SHU-HUI [US], et al
US 5283253 A 19940201 - HOLTON ROBERT A [US], et al
US 5279949 A 19940118 - NAIR MURALEEDHARAN G [US]
US 5274137 A 19931228 - NICOLAOU K C [US], et al
US 5202448 A 19930413 - CARVER DAVID R [US], et al
US 5200534 A 19930406 - RAO KOPPAKA V [US]
US 5229529 A 19930720 - UENO RYUJI [JP], et al
US 5254580 A 19931019 - CHEN SHU-HUI [US], et al
US 5412092 A 19950502 - REY ALLAN W [US], et al
US 5395850 A 19950307 - ROTH GREGORY [US]
US 5380751 A 19950110 - CHEN SHU-HUI [US], et al
US 5350866 A 19940927 - HOLTON ROBERT A [US], et al
US 4857653 A 19890815 - COLIN MICHEL [FR], et al
US 5272171 A 19931221 - UEDA YASUTSUGU [US], et al
US 5411984 A 19950502 - KINGSTON DAVID G I [US], et al
US 5248796 A 19930928 - CHEN SHU-HUI [US], et al
US 5422364 A 19950606 - NICOLAOU K C [US], et al
US 5300638 A 19940405 - FARINA VITTORIO [US], et al
US 5362831 A 19941108 - MONGELLI NICOLA [IT], et al
US 5440056 A 19950808 - KLEIN LARRY L [US], et al
US 4814470 A 19890321 - COLIN MICHEL [FR], et al
US 5278324 A 19940111 - KINGSTON DAVID G I [US], et al
US 5352805 A 19941004 - KINGSTON DAVID G I [US], et al
US 5059699 A 19911022 - KINGSTON DAVID G I [US], et al
US 4942184 A 19900717 - HAUGWITZ RUDIGER D [US], et al
US 87007904 A 20040617
WO 03006180 A1 20030123 - STICHTING TECH WETENSCHAPP [NL], et al
US 5292331 A 19940308 - BONEAU MICHAEL D [US]
US 6090127 A 20000718 - GLOBERMAN OREN [IL]
US 5133732 A 19920728 - WIKTOR DOMINIK M [US]
US 4739762 A 19880426 - PALMAZ JULIO C [US]
US 5421955 A 19950606 - LAU LILIP [US], et al
JEONG HOON LEE ET AL.: "Preparation and Characterization of Solvent Induced Dihydrate, Anhydrous and Amorphous Paclitaxel", BULL. KOREAN CHEM. SOC., vol. 22, no. 8, 2001, pages 925 - 928
PROC. NATL. ACAD. SCI. USA, vol. 92, July 1995 (1995-07-01), pages 6920 - 24
JEONG HOON LEE ET AL.: "Preparation and Characterization of Solvent Induced Dihydrated, Anhydrous and Amorphous Paclitaxel", BULL. KOREAN CHEM. SOC., vol. 22, no. 8, 2001, pages 925 - 928, XP009027328
E. L. ELIEL, S. H. WILEN: "Stereochemistry of Carbon Compounds", 1994, JOHN WILEY & SONS, pages: 1119 - 1190
FLEISHER ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 19, 1996, pages 115
"Design of Prodrugs", 1985, ELSEVIER
H. BUNDGAARD, DRUGS OF THE FUTURE, vol. 16, 1991, pages 443
SCHIFF ET AL., NATURE, vol. 277, 1979, pages 665 - 667
LONG, FAIRCHILD, CANCER RESEARCH, vol. 54, 1994, pages 4355 - 4361
RINGEL, HORWITZ, J. NAT'L CANCER INST., vol. 83, no. 4, 1991, pages 288 - 291
PAZDUR ET AL., CANCER TREAT. REV., vol. 19, no. 4, 1993, pages 351 - 386
TETRAHEDRON LETTERS, vol. 35, no. 52, 1994, pages 9709 - 9712
J. MED. CHEM., vol. 35, 1992, pages 4230 - 4237
J. MED. CHEM., vol. 34, 1991, pages 992 - 998
J. NATURAL PROD., vol. 57, no. 10, 1994, pages 1404 - 1410
J. NATURAL PROD., vol. 57, no. 11, 1994, pages 1580 - 1583
J. AM. CHEM. SOC., vol. 110, 1988, pages 6558 - 6560
J.H. LEE ET AL.: "Preparation and Characterization of Solvent Induced Dihydrated, Anhydrous and Amorphous Paclitaxel", BULL. KOREAN CHEM. SOC., vol. 22, no. 8, 2001, pages 925 - 928, XP009027328
R.T. LIGGINS ET AL.: "Solid-State Characterization of Paclitaxel", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 86, no. 12, December 1997 (1997-12-01), pages 1461, XP009027537, DOI: doi:10.1021/js9605226
R.T. LIGGINS ET AL.: "Solid-State Characterization of Paclitaxel", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 86, no. 12, December 1997 (1997-12-01), pages 1458 - 1463,1461, XP009027537, DOI: doi:10.1021/js9605226
R.T. LIGGINS ET AL.: "Solid-State Characterization of Paclitaxel", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 86, no. 12, December 1997 (1997-12-01), pages 1458 - 1463, XP009027537, DOI: doi:10.1021/js9605226

Citation (search report)

[X] US 6131600 A 20001017 - CHANG CHIA-BO [TW]
[I] KAMATH K R ET AL: "The Taxus(TM) drug-eluting stent: A new paradigm in controlled drug delivery", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 58, no. 3, 6 March 2006 (2006-03-06), pages 412 - 436, XP005481783, ISSN: 0169-409X, DOI: 10.1016/J.ADDR.2006.01.023

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2008005284 A2 20080110; WO 2008005284 A3 20090129; AT E519511 T1 20110815; EP 2043704 A2 20090408; EP 2043704 B1 20110810; EP 2043704 B2 20170419; EP 2380606 A1 20111026; EP 2380606 B1 20180321

DOCDB simple family (application)

US 2007015033 W 20070628; AT 07810005 T 20070628; EP 07810005 A 20070628; EP 11167978 A 20070628