EP 2382227 A1 20111102 - SULFURIZING REAGENTS AND THEIR USE FOR OLIGONUCLEOTIDES SYNTHESIS
Title (en)
SULFURIZING REAGENTS AND THEIR USE FOR OLIGONUCLEOTIDES SYNTHESIS
Title (de)
SCHWEFELUNGSREAGENZIEN UND IHRE VERWENDUNG IN DER OLIGONUKLEOTIDSYNTHESE
Title (fr)
RÉACTIFS DE SULFURISATION ET LEUR UTILISATION POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES
Publication
Application
Priority
- EP 2009067902 W 20091223
- US 14039108 P 20081223
Abstract (en)
[origin: WO2010072831A1] An oligonucleotide which comprises at least one internucleotide linkage comprising a P-S-R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH2, X and Y are independently selected from S and O, and R0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof.
IPC 8 full level
C07H 21/04 (2006.01); C07C 311/03 (2006.01); C07D 207/48 (2006.01)
CPC (source: EP KR)
C07C 311/03 (2013.01 - KR); C07C 313/36 (2013.01 - EP); C07D 207/48 (2013.01 - EP KR); C07H 21/00 (2013.01 - KR)
Citation (search report)
See references of WO 2010072831A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010072831 A1 20100701; CA 2747999 A1 20100701; CN 102307889 A 20120104; EP 2382227 A1 20111102; JP 2012513450 A 20120614; KR 20110099333 A 20110907
DOCDB simple family (application)
EP 2009067902 W 20091223; CA 2747999 A 20091223; CN 200980155288 A 20091223; EP 09799643 A 20091223; JP 2011542834 A 20091223; KR 20117017343 A 20091223