EP 2382235 B1 20160224 - NOVEL CAVIIDAE ALLERGEN AND USES THEREOF
Title (en)
NOVEL CAVIIDAE ALLERGEN AND USES THEREOF
Title (de)
NEUES CAVIIDAE-ALLERGEN UND ANWENDUNGEN DAVON
Title (fr)
NOUVEL ALLERGÈNE DE CAVIIDAE ET SES UTILISATIONS
Publication
Application
Priority
- EP 2009067604 W 20091218
- EP 08022207 A 20081219
- EP 09801699 A 20091218
Abstract (en)
[origin: WO2010070136A2] The present invention relates to the provision of a nucleic acid molecule encoding a Caviidae allergen comprising a polynucleotide selected from the group consisting of (a) a polynucleotide sequence as shown in SEQ ID NO 1 (Cav p 3), SEQ IDNO 5 (Cav p 2), SEQ ID NO 3 (Cav p 6) or SEQ ID NO 19 (Cavia porcellus allergen 1 a) or a fragment thereof, (b) a polynucleotide sequence encoding a polypeptide as shown in SEQ ID NO 2 (Cav p 3), SEQ IDNO 6 (Cav p 2), SEQ ID NO 4 (Cav p 6) or SEQ ID NO 20 (Cavia porcellus allergen 1 a) or a fragment thereof (c) a polynucleotide sequence which has at least 80% identity to the polynucleotides as defined in (a) or (b) encoding a Caviidae allergen or a fragment thereof, (d) a polynucleotide sequence encoding a polypeptide which has at least 85% identity to the polypeptide as shown in SEQ ID NO 2 (Cav p 3), SEQ ID NO 6 (Cav p 2), SEQ ID NO 4 (Cav p 6) or SEQ ID NO 20 (Cavia porcellus allergen 1a) or a fragment thereof, (e) a polynucleotide sequence which hybridizes to the polynucleotide sequence of any one of (a) to (d) and whereby the coding strand encodes a Caviidae allergen or a fragment thereof, (f) a polynucleotide sequence encoding a polypeptide as encoded by the nucleotide sequence of any one of (a) to (e) wherein at least one amino acid is deleted, substituted inserted or added and whereby said polynucleotide encodes a Caviidae allergen or a fragment thereof, and (g) a polynucleotide sequence being degenerate as a result of the generic code to the polynucleotide sequence as defined in any one of (a) to (f) The present invention also provides for a method for producing the polypeptides (Cav p3, Cav p6, Cavia porcellus allergen 1 a) encoded by said polynucleotides Moreover, the use of such allergens in a medical setting (e g in form of a pharmaceutical and/or diagnostic composition) an in vitro method for determining the allergenicity to Caviidae as well as an method for identifying potential antagonists or agonists of the polypeptides are also provided in the present invention.
IPC 8 full level
C07K 14/47 (2006.01); A61K 38/17 (2006.01)
CPC (source: EP US)
A61P 37/08 (2018.01 - EP); C07K 14/47 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010070136 A2 20100624; WO 2010070136 A3 20101007; EP 2382235 A2 20111102; EP 2382235 B1 20160224; US 2012087870 A1 20120412
DOCDB simple family (application)
EP 2009067604 W 20091218; EP 09801699 A 20091218; US 200913141050 A 20091218