EP 2385067 A1 20111109 - Artificial antibody polypeptides
Title (en)
Artificial antibody polypeptides
Title (de)
Künstliche Antikörperpolypeptide
Title (fr)
Polypeptides anticorps artificiels
Publication
Application
Priority
- EP 01955812 A 20010711
- US 21747400 P 20000711
Abstract (en)
The present invention provides a fibronectin type III(Fn3) molecule, wherein the Fn3 contains a stabilizing mutation. The present invention also provides Fn3 polypeptide monobodies, nucleic acid molecules encoding monobodies, and variegated nucleic acid molecules encoding monobodies, and variegated nucleic acid libraries encoding such monobodies. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform the methods.
IPC 8 full level
C07K 14/78 (2006.01); C12N 15/09 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/10 (2006.01); C12N 15/12 (2006.01); C12N 15/70 (2006.01); C12Q 1/68 (2006.01); C40B 30/04 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
C07K 14/78 (2013.01 - EP US); C07K 16/00 (2013.01 - EP US); C12N 15/1037 (2013.01 - US); C12N 15/1044 (2013.01 - EP US); C40B 30/04 (2013.01 - EP US); G01N 33/6845 (2013.01 - EP US); C07K 2317/565 (2013.01 - EP US)
Citation (applicant)
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Citation (search report)
- [X] WO 9856915 A2 19981217 - RES CORP TECHNOLOGIES INC [US]
- [A] WO 0034784 A1 20000615 - PHYLOS INC [US]
- [AD] E. BIANCHI ET AL.: "High level expression and rational mutagenesis of a designed protein, the minibody.", JOURNAL OF MOLECULAR BIOLOGY, vol. 236, 1994, London, GB, pages 649 - 659, XP000965177
- [A] A. KOIDE ET AL.: "The fibronectin type III domain as a scaffold for novel binding proteins.", JOURNAL OF MOLECULAR BIOLOGY, vol. 284, no. 4, 11 December 1998 (1998-12-11), London, GB, pages 1141 - 1151, XP002944100
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