EP 2386315 A1 20111116 - Methods for treating conditions associated with MASP-2 dependent complement activation

Title (en)

Methods for treating conditions associated with MASP-2 dependent complement activation

Title (de)

Verfahren zur Behandlung von Leiden in Zusammenhang mit MASP-2-abhängiger Komplementaktivierung

Title (fr)

Procédés pour le traitement d'états pathologiques liés à l'activation du complément MASP-2 dépendant

Publication

EP 2386315 A1 20111116 (EN)

Application

EP 10182826 A 20050609

Priority

EP 05765604 A 20050609
US 57884704 P 20040610

Abstract (en)

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C I q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASp-2 inhibitory agent and a pharmaceutically acceptable carrier.

IPC 8 full level

A61K 39/395 (2006.01); A61K 31/00 (2006.01); A61K 38/02 (2006.01); A61P 9/00 (2006.01); A61P 21/00 (2006.01); A61P 37/00 (2006.01); C07K 16/40 (2006.01)

CPC (source: EP US)

A01K 67/0276 (2013.01 - EP US); A61P 9/00 (2017.12 - EP US); C07K 16/40 (2013.01 - EP US); C12N 9/6424 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/55 (2013.01 - EP US)

Citation (applicant)

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DOCDB simple family (application)

US 2005020647 W 20050609; AU 2005254044 A 20050609; CA 2573144 A 20050609; CA 2847677 A 20050609; CA 2998633 A 20050609; CA 3102252 A 20050609; CN 200580026986 A 20050609; CN 201510121700 A 20050609; CY 161101035 T 20161017; CY 171100621 T 20170613; CY 171100623 T 20170613; DK 05765604 T 20050609; DK 10183893 T 20050609; DK 10184424 T 20050609; EP 05765604 A 20050609; EP 10182826 A 20050609; EP 10182836 A 20050609; EP 10183125 A 20050609; EP 10183216 A 20050609; EP 10183523 A 20050609; EP 10183546 A 20050609; EP 10183893 A 20050609; EP 10184424 A 20050609; EP 10184592 A 20050609; EP 10184696 A 20050609; EP 10184793 A 20050609; EP 10184806 A 20050609; EP 15196132 A 20050609; EP 19165032 A 20050609; ES 05765604 T 20050609; ES 10183216 T 20050609; ES 10183893 T 20050609; ES 10184424 T 20050609; HK 15112489 A 20151218; HU E05765604 A 20050609; HU E10183893 A 20050609; HU E10184424 A 20050609; LT 05765604 T 20050609; LT 10183893 T 20050609; LT 10184424 T 20050609; PL 05765604 T 20050609; PL 10183893 T 20050609; PL 10184424 T 20050609; PT 05765604 T 20050609; PT 10183893 T 20050609; PT 10184424 T 20050609; SI 200532150 T 20050609; SI 200532151 T 20050609; TR 201708554 T 20050609; US 15088305 A 20050609