EP 2389180 A4 20120815 - METHODS OF TREATING MUSCULAR DYSTROPHIES
Title (en)
METHODS OF TREATING MUSCULAR DYSTROPHIES
Title (de)
VERFAHREN ZUR BEHANDLUNG VON MUSKELDYSTROPHIEN
Title (fr)
PROCÉDÉS POUR LE TRAITEMENT DE DYSTROPHIES MUSCULAIRES
Publication
Application
Priority
- US 2010022068 W 20100126
- US 14746009 P 20090126
Abstract (en)
[origin: US2010190733A1] The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.
IPC 8 full level
A61P 21/00 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 31/7048 (2006.01)
CPC (source: EP US)
A61K 31/352 (2013.01 - EP US); A61K 31/353 (2013.01 - EP US); A61K 31/7048 (2013.01 - EP US); A61P 21/00 (2017.12 - EP)
Citation (search report)
- [X] WO 2007020917 A1 20070222 - UNIV TOKUSHIMA [JP], et al
- [X] US 6444221 B1 20020903 - SHAPIRO HOWARD K [US]
- [X] JP 2004337025 A 20041202 - SANGAKU RENKEI KIKO KYUSHU KK
- [XP] MESSINA S ET AL: "Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisolone", EXPERIMENTAL NEUROLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 220, no. 2, 25 September 2009 (2009-09-25), pages 349 - 358, XP026762287, ISSN: 0014-4886, [retrieved on 20090925], DOI: 10.1016/J.EXPNEUROL.2009.09.015
- See references of WO 2010085788A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
US 2010190733 A1 20100729; CA 2750761 A1 20100729; EP 2389180 A1 20111130; EP 2389180 A4 20120815; US 2013210753 A1 20130815; WO 2010085788 A1 20100729
DOCDB simple family (application)
US 69371110 A 20100126; CA 2750761 A 20100126; EP 10733995 A 20100126; US 2010022068 W 20100126; US 201213486016 A 20120601