EP 2389953 A1 20111130 - Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist

Title (en)

Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist

Title (de)

Verfahren zur Hemmung von Rezeptor-Tyrosinkinasen mit einem extrazellulären Antagonisten und einem intrazellulären Antagonisten

Title (fr)

Procédé d'inhibition de kinases de tyrosine de récepteur avec un antagoniste extracellulaire et antagoniste intracellulaire

Publication

EP 2389953 A1 20111130 (EN)

Application

EP 11004531 A 20040609

Priority

EP 04754904 A 20040609
US 47779603 P 20030609

Abstract (en)

The present invention relates to methods of inhibiting receptor tyrosine kinases by utilizing a combination of both an extracellular and an intracellular RTK antagonist. The extracellular RTK antagonist is a biological molecule or a small molecule that inhibits activation of the receptor tyrosine kinase by interacting with the extracellular binding region of the receptor. The intracellular RTK antagonist is a biological molecule or small molecule that inhibits tyrosine kinase activity of the receptor tyrosine kinase by interacting with the receptor's intracellular region bearing a kinase domain or by interacting with an intracellular protein involved in the signaling pathway of the receptor tyrosine kinase. The present invention also provides methods of treating tyrosine kinase-dependent diseases, and compositions for use in such methods thereof, by administering a combination of both an extracellular and an intracellular RTK antagonist.

IPC 8 full level

A61K 39/385 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01)

IPC 8 main group level

C12N (2006.01)

CPC (source: EP US)

A61K 39/385 (2013.01 - EP US); A61K 39/39558 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/26 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US)

Citation (applicant)

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Citation (search report)

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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL HR LT LV MK

DOCDB simple family (publication)

WO 2005001053 A2 20050106; WO 2005001053 A3 20050811; BR PI0411250 A 20060829; CA 2528961 A1 20050106; CN 101966338 A 20110209; CN 1972712 A 20070530; EP 1638600 A2 20060329; EP 1638600 A4 20080611; EP 2389953 A1 20111130; IL 172473 A0 20060410; JP 2007500248 A 20070111; JP 2012211158 A 20121101; RU 2006100030 A 20070720; RU 2011122542 A 20121220; RU 2431500 C2 20111020; TN SN05315 A1 20070710; US 2007036795 A1 20070215; US 2009232805 A1 20090917; US 2012201817 A1 20120809

DOCDB simple family (application)

US 2004018451 W 20040609; BR PI0411250 A 20040609; CA 2528961 A 20040609; CN 200480022754 A 20040609; CN 201010505934 A 20040609; EP 04754904 A 20040609; EP 11004531 A 20040609; IL 17247305 A 20051208; JP 2006533679 A 20040609; JP 2012134885 A 20120614; RU 2006100030 A 20040609; RU 2011122542 A 20110606; TN SN05315 A 20051208; US 201213445239 A 20120412; US 36135009 A 20090128; US 56020904 A 20040609