EP 2390323 B1 20131127 - Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders
Title (en)
Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders
Title (de)
Faktor-IX-Varianten mit Gerinnungsaktivität in Abwesenheit ihres Cofaktors und ihre Verwendung zur Behandlung von Blutungsstörungen
Title (fr)
Variantes du facteur IX dotées d´activité de coagulation en l´absence de leur cofacteur et leur utilisation pour le traitement de troubles du sang
Publication
Application
Previously filed application
09777493 20090728 EP
Priority
- EP 09777493 A 20090728
- EP 08013561 A 20080728
- EP 11005215 A 20090728
Abstract (en)
[origin: EP2149603A1] The present invention relates to variants of a vitamin K-dependent serine protease of the coagulation cascade, preferably variants of factor IX (F.IX), wherein the variant is characterized in that it has clotting activity in absence of its cofactor. The present invention furthermore relates to the use of these variants for the treatment and/or prophylaxis of bleeding disorders, in particular hemophilia A and/or hemophilia B or hemophilia caused or complicated by inhibitory antibodies to F.VIII. The present invention also relates to further variants of factor IX (F.IX) which have desired properties and can, thus be tailored for respective specific therapeutic applications.
IPC 8 full level
C12N 9/64 (2006.01)
CPC (source: EP KR US)
A61P 7/04 (2017.12 - EP); C12N 9/644 (2013.01 - EP KR US); C12Y 304/21022 (2013.01 - EP US); G01N 33/6893 (2013.01 - KR); A61K 38/00 (2013.01 - KR); C12Y 304/21022 (2013.01 - KR); G01N 2333/9645 (2013.01 - KR); G01N 2800/224 (2013.01 - KR)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2149603 A1 20100203; AU 2009275391 A1 20100204; AU 2009275391 B2 20150122; CA 2729501 A1 20100204; CA 2729501 C 20190402; CA 3033578 A1 20100204; CA 3033578 C 20220726; CN 102112608 A 20110629; CN 102112608 B 20131120; EP 2318526 A1 20110511; EP 2390323 A2 20111130; EP 2390323 A3 20120111; EP 2390323 B1 20131127; EP 2767587 A2 20140820; EP 2767587 A3 20141126; EP 2767587 B1 20170405; EP 3241899 A1 20171108; EP 3241899 B1 20190821; EP 3623470 A2 20200318; EP 3623470 A3 20200722; ES 2441167 T3 20140203; ES 2628688 T3 20170803; ES 2753638 T3 20200413; JP 2011528913 A 20111201; JP 6029826 B2 20161124; KR 101768896 B1 20170817; KR 101947424 B1 20190213; KR 20110036071 A 20110406; KR 20170096210 A 20170823; US 10125357 B2 20181113; US 10883097 B2 20210105; US 2011217284 A1 20110908; US 2019017039 A1 20190117; WO 2010012451 A1 20100204
DOCDB simple family (application)
EP 08013561 A 20080728; AU 2009275391 A 20090728; CA 2729501 A 20090728; CA 3033578 A 20090728; CN 200980129669 A 20090728; EP 09777493 A 20090728; EP 11005215 A 20090728; EP 14165396 A 20090728; EP 17164245 A 20090728; EP 19191719 A 20090728; EP 2009005465 W 20090728; ES 11005215 T 20090728; ES 14165396 T 20090728; ES 17164245 T 20090728; JP 2011520375 A 20090728; KR 20117001765 A 20090728; KR 20177022245 A 20090728; US 200913001187 A 20090728; US 201816148819 A 20181001