EP 2391637 A1 20111207 - NOVEL PEPTIDE-HOMOLOGUES FOR INHIBITING BETA1-ADRENOCEPTOR ANTIBODIES
Title (en)
NOVEL PEPTIDE-HOMOLOGUES FOR INHIBITING BETA1-ADRENOCEPTOR ANTIBODIES
Title (de)
NEUE PEPTIDHOMOLOGE ZUM INHIBIEREN VON BETA1-ADRENOZEPTOR-ANTIKÖRPERN
Title (fr)
NOUVEAUX HOMOLOGUES PEPTIDIQUES POUR L'INHIBITION D'ANTICORPS DIRIGÉS CONTRE L'ADRÉNORÉCEPTEUR BÊTA1
Publication
Application
Priority
- EP 2010050949 W 20100127
- US 20609109 P 20090127
Abstract (en)
[origin: WO2010086337A1] The present invention relates to novel ß-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage and comprising an a-aminobutyric acid (ABu) residue, or an analogue thereof, which replaces the cysteine residue corresponding to cysteine 216 of the human ß1-AR amino-acid sequence. The present invention further relates to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding peptides from which these cyclopeptide-mutants and linear peptides can be manufactured. Moreover, vectors comprising the nucleic acid molecules and recombinant host cells comprising the nucleic acid molecules or vectors are provided. Further, a method for producing the disclosed cyclopeptide-mutants is provided. Further disclosed is a composition comprising the peptide(s), nucleic acid molecuie(s), vector(s) or host cell(s) of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptide(s) of the invention and to means, methods and uses for detecting anti-ß- adrenergic receptor antibodies, in particular anti-ß1 -adrenergic receptor antibodies.
IPC 8 full level
C07K 7/64 (2006.01); C07K 14/705 (2006.01)
CPC (source: EP)
C07K 14/70571 (2013.01)
Citation (search report)
See references of WO 2010086337A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010086337 A1 20100805; BR PI1007007 A2 20160322; EP 2391637 A1 20111207; MX 2011007882 A 20111104
DOCDB simple family (application)
EP 2010050949 W 20100127; BR PI1007007 A 20100127; EP 10706168 A 20100127; MX 2011007882 A 20100127