EP 2393792 A1 20111214 - DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
Title (en)
DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
Title (de)
DERIVATE VON 6-(6-NH-SUBSTITUIERTEN TRIAZOLOPYRIDAZINSULFANYL)BENZOTHIAZOLEN UND BENZIMIDAZOLEN, DEREN HERSTELLUNG, DEREN VERWENDUNG ALS ARZNEIMITTEL UND DEREN VERWENDUNG ALS MET-INHIBITOREN
Title (fr)
DERIVES DE 6-(6-NH-SUBSTITUE-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES ET BENZIMIDAZOLES : PREPARATION, APPLICATION COMME MEDICAMENTS ET UTILISATION COMME INHIBITEURS DE MET
Publication
Application
Priority
- FR 2010050179 W 20100204
- FR 0900513 A 20090206
Abstract (en)
[origin: WO2010089508A1] The invention relates to novel products of the formula (I) where: (II) is a single or double bond; Rb is a hydrogen or fluorine atom; Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical; X is S, SO, or SO2; A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; -O- (CH2)n-phenyl with n= 1 to 4; or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH; all of said radicals being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
IPC 8 full level
A61K 31/5025 (2006.01); A61P 35/00 (2006.01); C07D 277/82 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61K 31/5025 (2013.01 - KR); A61P 3/00 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 21/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 27/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 277/82 (2013.01 - EP US); C07D 403/12 (2013.01 - KR); C07D 487/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2010089508A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010089508 A1 20100812; AR 075250 A1 20110316; AU 2010212233 A1 20110825; BR PI1008188 A2 20160308; CA 2751539 A1 20100812; CN 102369192 A 20120307; EP 2393792 A1 20111214; FR 2941951 A1 20100813; FR 2941951 B1 20110401; IL 214404 A0 20110927; JP 2012517409 A 20120802; KR 20110126658 A 20111123; MX 2011008310 A 20111102; RU 2011136855 A 20130320; SG 173562 A1 20110929; TW 201033214 A 20100916; US 2012040987 A1 20120216; UY 32421 A 20100930
DOCDB simple family (application)
FR 2010050179 W 20100204; AR P100100318 A 20100205; AU 2010212233 A 20100204; BR PI1008188 A 20100204; CA 2751539 A 20100204; CN 201080015591 A 20100204; EP 10708279 A 20100204; FR 0900513 A 20090206; IL 21440411 A 20110802; JP 2011548752 A 20100204; KR 20117020674 A 20100204; MX 2011008310 A 20100204; RU 2011136855 A 20100204; SG 2011056512 A 20100204; TW 99103591 A 20100205; US 201013147297 A 20100204; UY 32421 A 20100205