EP 2393793 A1 20111214 - DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
Title (en)
DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
Title (de)
DERIVATE VON 6-(6-SUBSTITUIERTEN TRIAZOLOPYRIDAZINSULFANYL)-5- FLUORBENZOTHIAZOLEN UND -5-FLUORBENZIMIDAZOLEN, DEREN HERSTELLUNG, DEREN VERWENDUNG ALS ARZNEIMITTEL UND DEREN VERWENDUNG ALS MET-INHBITIOREN
Title (fr)
DERIVES DE 6-(6-SUBSTITUE-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO-BENZOTHIAZOLES ET 5-FLUORO-BENZIMIDAZOLES : PREPARATION, APPLICATION COMME MEDICAMENTS ET UTILISATION COMME INHIBITEURS DE MET
Publication
Application
Priority
- FR 2010050180 W 20100204
- FR 0900514 A 20090206
Abstract (en)
[origin: WO2010089509A1] The invention relates to novel products of the formula (I) where: (II) is a single or double bond; F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, -O- heterocycloalkyl; -NH-cycloalkyl, -NH-heterocycloalkyl, heteroaryl, phenyl, NHCOaIk, NHCOcycloalk or NR1 R2; X is S, SO or SO2, A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl, or heterocycloalkyl; alkoxy optionally substituted by NR3R4, i.e. a O-(CH2)n-NR3R4 radical, an O-phenyl or an O-(CH2)n-phenyl radical, with phenyl optionally substituted and n = 1 to 4; or the NR1 R2 radical; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and/or R3,R4 form a cycle together with N optionally containing O, S, N and/or NH; heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
IPC 8 full level
A61K 31/5025 (2006.01); A61P 35/00 (2006.01); C07D 277/82 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61K 31/5025 (2013.01 - KR); A61P 3/00 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 27/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 277/82 (2013.01 - EP US); C07D 403/12 (2013.01 - KR); C07D 487/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2010089509A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010089509 A1 20100812; AR 075251 A1 20110316; AU 2010212234 A1 20110825; BR PI1008019 A2 20160315; CA 2751474 A1 20100812; CN 102369191 A 20120307; CO 6420339 A2 20120416; EA 201171012 A1 20120330; EP 2393793 A1 20111214; FR 2941952 A1 20100813; FR 2941952 B1 20110401; IL 214408 A0 20110927; JP 2012517410 A 20120802; KR 20110126659 A 20111123; MA 33103 B1 20120301; MX 2011008290 A 20111104; SG 173561 A1 20110929; TW 201036977 A 20101016; US 2012165326 A1 20120628; UY 32422 A 20100930
DOCDB simple family (application)
FR 2010050180 W 20100204; AR P100100319 A 20100205; AU 2010212234 A 20100204; BR PI1008019 A 20100204; CA 2751474 A 20100204; CN 201080015563 A 20100204; CO 11099118 A 20110805; EA 201171012 A 20100204; EP 10708280 A 20100204; FR 0900514 A 20090206; IL 21440811 A 20110802; JP 2011548753 A 20100204; KR 20117020675 A 20100204; MA 34148 A 20110905; MX 2011008290 A 20100204; SG 2011056504 A 20100204; TW 99103557 A 20100205; US 201013147644 A 20100204; UY 32422 A 20100205