EP 2396301 A2 20111221 - SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS
Title (en)
SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS
Title (de)
NIEDERMOLEKULARE ANTAGONISTEN DES BRADYKININ-B1-REZEPTORS
Title (fr)
PETITES MOLÉCULES ANTAGONISTES DU RÉCEPTEUR B1 DE LA BRADYKININE
Publication
Application
Priority
- EP 2010000883 W 20100212
- EP 09002073 A 20090213
- EP 10705103 A 20100212
Abstract (en)
[origin: WO2010091876A2] The present invention is related to a compound of the formula (I): or a pharmacologically acceptable salt, solvate or hydrate thereof, wherein A is formula (II) (III) (IV), X is Ch or N; R1, R2, R3, R4, R6, R7, and R8 are each and independently of each other selected from hydrogen atom, halogen atom, hydroxy, cyano, amino, alkyl, or optionally substituted heteroalkyl; R5 is a halogen atom, hydroxy, cyano, amino, an alkyl, an optionally substituted heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted alkylcycloalkyl, an optionally substituted heteroalkylcycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; R9 is a hydrogen atom, an alkyl, or a heteroalkyl; R10 is a hydrogen atom, an alkyl, an optionally substituted heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; R11 is an alkyl, an optionally substituted heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted alkylcycloalkyl, an optionally substituted heteroalkylcycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; R12 is a hydrogen atom, an alkyl, an optionally substituted heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; B is O or N; Z1 and Z2 are each and independently of each other selected from C or N, and Z3 and Z4 are each and independently of each other selected from C, S, O or N; R13 is an alkyl, an optionally substituted heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted alkylcycloalkyl, an optionally substituted heteroalkylcycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; R14 and R15, if present, are (i) each and independently of each other selected from hydrogen atom, halogen atom, CN, hydroxy, =O, alkyl, C3-C6-cycloalkyl, heteroalkyl or alkoxy; or (ii) joined together to form a carbocyclic or heterocyclic 5- or 6-membered ring, which is substituted with 0 to 4 substituents selected from the group comprising R16, R17, R18 and R19, and is saturated, unsaturated, or aromatic, and, if heterocyclic, contains one or more heteroatom(s) each and independently selected from N, O and S; and R16, R17, R18 and R19 are individually and independently selected from hydrogen atom, halogen atom, hydroxy, cyano, amino, alkyl, and optionally substituted heteroalkyl.
IPC 8 full level
C07D 213/40 (2006.01); C07D 213/61 (2006.01); C07D 213/89 (2006.01); C07D 235/30 (2006.01); C07D 239/28 (2006.01); C07D 257/04 (2006.01); C07D 261/18 (2006.01); C07D 271/06 (2006.01); C07D 285/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 409/10 (2006.01); C07D 409/12 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP)
C07C 281/06 (2013.01); C07D 213/40 (2013.01); C07D 213/61 (2013.01); C07D 213/89 (2013.01); C07D 235/30 (2013.01); C07D 239/28 (2013.01); C07D 257/04 (2013.01); C07D 261/18 (2013.01); C07D 271/06 (2013.01); C07D 285/06 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 409/10 (2013.01); C07D 409/12 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 2010091876A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010091876 A2 20100819; WO 2010091876 A3 20101223; CA 2752190 A1 20100819; EP 2396301 A2 20111221
DOCDB simple family (application)
EP 2010000883 W 20100212; CA 2752190 A 20100212; EP 10705103 A 20100212