EP 2396334 A1 20111221 - N-[(2-AZABICYCLO[2.1.1]HEX-1-YL]-ARYL-METHYL]-BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
Title (en)
N-[(2-AZABICYCLO[2.1.1]HEX-1-YL]-ARYL-METHYL]-BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
Title (de)
N-[(2-AZABICYCLO[2.1.1]HEX-1-YL]ARYLMETHYL] BENZAMIDDERIVATE, DEREN HERSTELLUNG UND DEREN THERAPEUTISCHE VERWENDUNG
Title (fr)
DERIVES DE N-[(2-AZA-BICYCLO[2.1.1]HEX-1-YL]-ARYL-METHYL]-BENZAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
Publication
Application
Priority
- FR 2010050203 W 20100209
- FR 0900578 A 20090210
Abstract (en)
[origin: WO2010092286A1] The invention relates to N-[(2-aza-bicyclo[2.2.1]hex-1-yl)-aryl-methyl]-benzamide derivatives of the general formula (I) where: R is a hydrogen atom or a (C1-C6)alkyl group, (C3-C7)-cycloalkyl, optionally substituted by one or more fluorine, (C3-C7)-cycloalkyl, (C2-C4)alkenyl, phenyl, (C1-C6)alkoxy, hydroxy; R1 is phenyl or naphtyl optionally substituted by one or more halogen, (C1-C6)alkyl, (C1-C6)alkoxy, halo-(C1-C6)alkyl, NR4R5, (C1-C6)alkylthio, (C1-C6)alkyl-SO2, phenyl or heteroaryl,; R2 is one or more hydrogen or halogen atoms, halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)alkyl; R3, R4 and R5 are independently a hydrogen atom or a (C1-C6)alkyl group; R6 is a (C1-C6)alkyl group; R3 and R4 as well as R3 and R6 may form, together with the atoms having them, a 5- or 6-member ring; R4 and R5 may form together a ring selected from azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, piperazine, azepine, optionally substituted by a (C1-C6)alkyl group. The invention also relates to the therapeutic use thereof and to a method for synthesizing same.
IPC 8 full level
A61K 31/407 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/32 (2006.01); C07D 487/08 (2006.01)
CPC (source: EP KR US)
A61K 31/407 (2013.01 - KR); A61P 15/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 29/00 (2017.12 - EP); C07D 209/52 (2013.01 - KR); C07D 487/08 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2010092286A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
FR 2941953 A1 20100813; FR 2941953 B1 20110408; AR 075379 A1 20110330; AU 2010212702 A1 20110901; BR PI1008660 A2 20160308; CA 2751863 A1 20100819; CN 102388049 A 20120321; EP 2396334 A1 20111221; IL 214490 A0 20110927; JP 2012517411 A 20120802; KR 20110118812 A 20111101; MX 2011008447 A 20111129; RU 2011137463 A 20130320; SG 173606 A1 20110929; TW 201036979 A 20101016; US 2012071536 A1 20120322; UY 32428 A 20100930; WO 2010092286 A1 20100819
DOCDB simple family (application)
FR 0900578 A 20090210; AR P100100344 A 20100209; AU 2010212702 A 20100209; BR PI1008660 A 20100209; CA 2751863 A 20100209; CN 201080015019 A 20100209; EP 10708303 A 20100209; FR 2010050203 W 20100209; IL 21449011 A 20110807; JP 2011548758 A 20100209; KR 20117021203 A 20100209; MX 2011008447 A 20100209; RU 2011137463 A 20100209; SG 2011057205 A 20100209; TW 99104005 A 20100209; US 201013148583 A 20100209; UY 32428 A 20100210