EP 2396365 A2 20111221 - REDUCIBLE POLYMERS FOR NON-VIRAL GENE DELIVERY
Title (en)
REDUCIBLE POLYMERS FOR NON-VIRAL GENE DELIVERY
Title (de)
REDUZIERBARE POLYMERE FÜR NICHTVIRALE GENFREISETZUNG
Title (fr)
POLYMÈRES RÉDUCTIBLES POUR L'ADMINISTRATION DE GÈNES NON VIRAUX
Publication
Application
Priority
- US 2010000390 W 20100211
- US 20739209 P 20090211
Abstract (en)
[origin: WO2010093452A2] Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The biodegradable copolymers may comprise a reducible polymer linearly modified with lysine, such as a linear lysine-modified N,N'-cystamine bisacrylamide. The biodegradable copolymers also may be conjugated to a sequestering moiety, such as dietheylamine. The biodegradable copolymers also may comprise one or both of a targeting moiety and one or more moieties to facilitate endosomal escape. Also provided are methods for treating a pathophysiological condition and for increasing biocompatibility of a polymeric delivery system upon delivery to a subject using the biodegradable copolymers and nanoplexes.
IPC 8 full level
A61K 9/16 (2006.01); A61K 31/7105 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C08G 69/10 (2006.01); C08G 69/48 (2006.01); C08L 101/16 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61K 31/7105 (2013.01); A61K 47/34 (2013.01); A61K 47/59 (2017.07); A61K 47/595 (2017.07); C08G 69/10 (2013.01); C08G 69/48 (2013.01); C12N 15/87 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010093452 A2 20100819; WO 2010093452 A3 20101125; EP 2396365 A2 20111221; EP 2396365 A4 20131030
DOCDB simple family (application)
US 2010000390 W 20100211; EP 10741516 A 20100211