Global Patent Index - EP 2396365 A4

EP 2396365 A4 20131030 - REDUCIBLE POLYMERS FOR NON-VIRAL GENE DELIVERY

Title (en)

REDUCIBLE POLYMERS FOR NON-VIRAL GENE DELIVERY

Title (de)

REDUZIERBARE POLYMERE FÜR NICHTVIRALE GENFREISETZUNG

Title (fr)

POLYMÈRES RÉDUCTIBLES POUR L'ADMINISTRATION DE GÈNES NON VIRAUX

Publication

EP 2396365 A4 20131030 (EN)

Application

EP 10741516 A 20100211

Priority

  • US 2010000390 W 20100211
  • US 20739209 P 20090211

Abstract (en)

[origin: WO2010093452A2] Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The biodegradable copolymers may comprise a reducible polymer linearly modified with lysine, such as a linear lysine-modified N,N'-cystamine bisacrylamide. The biodegradable copolymers also may be conjugated to a sequestering moiety, such as dietheylamine. The biodegradable copolymers also may comprise one or both of a targeting moiety and one or more moieties to facilitate endosomal escape. Also provided are methods for treating a pathophysiological condition and for increasing biocompatibility of a polymeric delivery system upon delivery to a subject using the biodegradable copolymers and nanoplexes.

IPC 8 full level

C08G 69/48 (2006.01); A61K 9/16 (2006.01); A61K 31/7105 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C08G 69/10 (2006.01); C08L 101/16 (2006.01); C12N 15/87 (2006.01)

CPC (source: EP)

A61K 31/7105 (2013.01); A61K 47/34 (2013.01); A61K 47/59 (2017.07); A61K 47/595 (2017.07); C08G 69/10 (2013.01); C08G 69/48 (2013.01); C12N 15/87 (2013.01)

Citation (search report)

  • [XP] WO 2009061456 A2 20090514 - UNIV HOUSTON [US]
  • [X] MALAVOSKLISH BIKRAM ET AL: "-lysine)- g -histidine Multiblock Copolymers for Nonviral Gene Delivery", MACROMOLECULES, vol. 37, no. 5, 1 March 2004 (2004-03-01), pages 1903 - 1916, XP055079715, ISSN: 0024-9297, DOI: 10.1021/ma035650c
  • [X] AHN C-H ET AL: "Synthesis of biodegradable multi-block copolymers of poly(l-lysine) and poly(ethylene glycol) as a non-viral gene carrier", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 97, no. 3, 7 July 2004 (2004-07-07), pages 567 - 574, XP004519519, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2004.04.002
  • [X] PARKER ET AL: "(LYS)16-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - GENERAL SUBJECTS, ELSEVIER, vol. 1770, no. 9, 16 August 2007 (2007-08-16), pages 1331 - 1337, XP022201959, ISSN: 0304-4165, DOI: 10.1016/J.BBAGEN.2007.06.009
  • [X] READ M L ET AL: "A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD, vol. 33, no. 9, 1 May 2005 (2005-05-01), pages e86 - 1, XP002447464, ISSN: 0305-1048, [retrieved on 20050524], DOI: 10.1093/NAR/GNI085
  • [X] READ M L ET AL: "Vectors based on reducible polycations facilitate intracellular release of nucleic acids", JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS, INC, US, vol. 5, no. 3, 1 March 2003 (2003-03-01), pages 232 - 245, XP002481542, ISSN: 1099-498X, DOI: 10.1002/JGM.331
  • See references of WO 2010093452A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010093452 A2 20100819; WO 2010093452 A3 20101125; EP 2396365 A2 20111221; EP 2396365 A4 20131030

DOCDB simple family (application)

US 2010000390 W 20100211; EP 10741516 A 20100211