EP 2399573 A1 20111228 - Compositions comprising poorly water soluble pharmaceutical agents
Title (en)
Compositions comprising poorly water soluble pharmaceutical agents
Title (de)
Zusammensetzungen aus schwer wasserlöslichen pharmazeutischen Mitteln
Title (fr)
Compositions comprenant des agents pharmaceutiques peu solubles dans l'eau
Publication
Application
Priority
- US 71286505 P 20050831
- US 73693105 P 20051114
- US 73696205 P 20051114
- EP 06813980 A 20060830
- US 2006033931 W 20060830
Abstract (en)
The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
IPC 8 full level
A61K 9/51 (2006.01); A61K 9/19 (2006.01); A61K 31/337 (2006.01); A61K 38/13 (2006.01); A61K 45/06 (2006.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01)
CPC (source: EP KR NO US)
A61K 9/0019 (2013.01 - EP NO US); A61K 9/19 (2013.01 - EP KR NO US); A61K 9/51 (2013.01 - NO); A61K 9/5169 (2013.01 - EP US); A61K 31/337 (2013.01 - EP KR NO US); A61K 38/13 (2013.01 - EP NO US); A61K 45/06 (2013.01 - EP NO US); A61K 47/02 (2013.01 - US); A61K 47/12 (2013.01 - EP NO US); A61K 47/18 (2013.01 - NO); A61K 47/183 (2013.01 - US); A61K 47/26 (2013.01 - EP KR NO US); A61K 47/42 (2013.01 - EP KR NO US); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); Y02A 50/30 (2018.01 - US); Y10S 977/702 (2013.01 - EP US); Y10S 977/705 (2013.01 - EP US); Y10S 977/773 (2013.01 - EP US); Y10S 977/788 (2013.01 - EP US); Y10T 428/2982 (2015.01 - EP US)
C-Set (source: EP US)
Citation (applicant)
- US 5714520 A 19980203 - JONES CHRISTOPHER BUCHAN [GB], et al
- US 5731355 A 19980324 - JONES CHRISTOPHER BUCHAN [GB], et al
- US 5731356 A 19980324 - JONES CHRISTOPHER BUCHAN [GB], et al
- US 6028108 A 20000222 - GEORGE MARY MATHEW [US]
- US 6100302 A 20000808 - PEJAVER SATISH K [US], et al
- US 6147122 A 20001114 - MIREJOVSKY DORLA [US], et al
- US 6177477 B1 20010123 - GEORGE MARY MATHEW [US], et al
- US 6399087 B1 20020604 - ZHANG JACK YONGFENG [US], et al
- US 6469069 B1 20021022 - MIREJOVSKY DORLA [US], et al
- WO 9939696 A1 19990812 - GENSIA SICOR INC [US]
- US 2005004002 A1 20050106 - DESAI NEIL P [US], et al
- US 2004009168 A1 20040115 - KAISHEVA ELIZABET [US], et al
- US 5916596 A 19990629 - DESAI NEIL P [US], et al
- US 6096331 A 20000801 - DESAI NEIL P [US], et al
- US 6749868 B1 20040615 - DESAI NEIL P [US], et al
- US 6537539 B2 20030325 - LI YI [US], et al
- US 6506405 B1 20030114 - DESAI NEIL P [US], et al
- US 6537579 B1 20030325 - DESAI NEIL P [US], et al
- US 2005152979 A1 20050714 - BESMAN MARC [US], et al
- US 2006006167 A1 20060112 - KOPEL ZEV [CA]
- US 5439686 A 19950808 - DESAI NEIL P [US], et al
- BRIGGS ET AL., ANESTHESIS, vol. 37, 1982, pages 1099
- WAUGH ET AL., AM. J HOSP. PHARMACISTS, vol. 48, 1991, pages 1520
- GELDERBLOM ET AL., EUR. J OF CANCER, vol. 37, 2001, pages 1590 - 1598
- BAKER ET AL., ANESTHESIOLOGY, vol. 103, no. 4, 2005, pages 1 - 17
- MIREJOVSKY, AM. J HEALTH SYST. PHARM., vol. 58, 2001, pages 1047
- LAM ET AL., PHARM. RES., vol. 14, 1997, pages 725 - 729
- SUTTON, PORTER, PDA J PHARM. SCI. TECH., vol. 56, no. 6, 2002, pages 300 - 311
- "Therapeutic Category and Biological Activity Index", 1996, THE MERCK INDEX
- TULLIS, JAMA, vol. 237, 1977, pages 355 - 360,460-463
- HOUSER ET AL., SURGERY, GYNECOLOGY AND OBSTETRICS, vol. 150
- FINLAYSON, SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 6, 1980, pages 85 - 120
- GOODMAN ET AL.: "The Pharmacological Basis of Therapeutics", 1996, MCGRAW-HILL
- FEHSKE ET AL., BIOCHEM. PHARMCOL., vol. 30, 1981, pages 687 - 92
- VORUM, DAN. MED. BULL., vol. 46, 1999, pages 379 - 99
- KRAGH-HANSEN, DAN. MED. BULL., vol. 1441, 1990, pages 131 - 40
- CURRY ET AL., NAT. STRUCT. BIOL., vol. 5, 1998, pages 827 - 35
- SUGIO ET AL., PROTEIN. ENG., vol. 12, 1999, pages 439 - 46
- HE ET AL., NATURE, vol. 358, 1992, pages 209 - 15
- CARTER ET AL., ADV. PROTEIN. CHEM., vol. 45, 1994, pages 153 - 203
- PAAL ET AL., EUR. J BIOCHEM., vol. 268, no. 7, 2001, pages 2187 - 91
- PURCELL ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1478, no. 1, 2000, pages 61 - 8
- ALTMAYER, ARZNEIMITTELFORSCHUNG, vol. 45, 1995, pages 1053 - 6
- GARRIDO ET AL., REV. ESP. ANESTESTIOL. REANIM., vol. 41, 1994, pages 308 - 12
- URIEN ET AL., INVEST. NEW DRUGS, vol. 14, no. 2, 1996, pages 147 - 51
Citation (search report)
- [X] US 6506405 B1 20030114 - DESAI NEIL P [US], et al
- [X] WO 0006152 A1 20000210 - NOVOPHARM BIOTECH INC [CA], et al
- [I] US 2005004002 A1 20050106 - DESAI NEIL P [US], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007027819 A2 20070308; WO 2007027819 A3 20070426; AU 2006284808 A1 20070308; AU 2006284808 B2 20120816; BR PI0615265 A2 20110517; BR PI0615265 A8 20180306; CA 2620585 A1 20070308; CA 2620585 C 20150428; CA 2848021 A1 20070308; CA 2848021 C 20161213; CA 2880727 A1 20070308; CA 2880727 C 20190507; CN 101291659 A 20081022; CN 103054798 A 20130424; CN 103054798 B 20210316; CN 104189905 A 20141210; CY 1121461 T1 20200529; CY 1123047 T1 20211029; DK 1931321 T3 20190415; DK 3311805 T3 20200414; EP 1931321 A2 20080618; EP 1931321 B1 20181226; EP 2399573 A1 20111228; EP 2399573 B1 20190102; EP 2404594 A1 20120111; EP 2404594 B1 20171220; EP 3311805 A1 20180425; EP 3311805 B1 20200115; EP 3659589 A1 20200603; ES 2663324 T3 20180412; ES 2718323 T3 20190701; ES 2720603 T3 20190723; ES 2784794 T3 20201001; HK 1252388 A1 20190524; HU E042678 T2 20190729; HU E048521 T2 20200828; IL 189601 A0 20080807; IL 189601 A 20160421; IL 245152 A0 20160630; IL 245152 B 20200227; IL 272235 A 20200227; JP 2009506126 A 20090212; JP 2013213069 A 20131017; JP 5461837 B2 20140402; KR 101420445 B1 20140716; KR 20080065600 A 20080714; LT 1931321 T 20190510; LT 3311805 T 20200427; NO 20081543 L 20080513; NO 20191301 A1 20080513; NO 343593 B1 20190408; NO 345390 B1 20210111; NZ 566696 A 20120330; PL 1931321 T3 20190830; PL 3311805 T3 20200727; PT 1931321 T 20190514; PT 3311805 T 20200421; RU 2008112144 A 20091010; RU 2008112146 A 20091010; RU 2433818 C2 20111120; RU 2451510 C2 20120527; SI 1931321 T1 20190731; SI 3311805 T1 20200731; TR 200801336 T1 20080821; TR 200801337 T1 20080721; TW 200744639 A 20071216; TW 200744677 A 20071216; TW I417114 B 20131201; TW I429452 B 20140311; US 2007117744 A1 20070524; US 2011118342 A1 20110519; US 2011151012 A1 20110623; US 2011196026 A1 20110811; US 2012308612 A1 20121206; US 2017007569 A1 20170112; US 2019343789 A1 20191114; US 7771751 B2 20100810; US 9308180 B2 20160412; ZA 200802765 B 20090826
DOCDB simple family (application)
US 2006033931 W 20060830; AU 2006284808 A 20060830; BR PI0615265 A 20060830; CA 2620585 A 20060830; CA 2848021 A 20060830; CA 2880727 A 20060830; CN 200680038771 A 20060830; CN 201210585716 A 20060830; CN 201410319045 A 20060830; CY 191100347 T 20190326; CY 201100334 T 20200408; DK 06813980 T 20060830; DK 17202081 T 20060830; EP 06813980 A 20060830; EP 11169998 A 20060830; EP 11170007 A 20060830; EP 17202081 A 20060830; EP 20151407 A 20060830; ES 06813980 T 20060830; ES 11169998 T 20060830; ES 11170007 T 20060830; ES 17202081 T 20060830; HK 18111685 A 20180912; HU E06813980 A 20060830; HU E17202081 A 20060830; IL 18960108 A 20080219; IL 24515216 A 20160417; IL 27223520 A 20200126; JP 2008529249 A 20060830; JP 2013151445 A 20130722; KR 20087007604 A 20060830; LT 06813980 T 20060830; LT 17202081 T 20060830; NO 20081543 A 20080328; NO 20191301 A 20191030; NZ 56669606 A 20060830; PL 06813980 T 20060830; PL 17202081 T 20060830; PT 06813980 T 20060830; PT 17202081 T 20060830; RU 2008112144 A 20060830; RU 2008112146 A 20060830; SI 200632324 T 20060830; SI 200632373 T 20060830; TR 200801336 T 20060830; TR 200801337 T 20060830; TW 95132009 A 20060830; TW 95132027 A 20060830; US 201213408994 A 20120229; US 201615178469 A 20160609; US 201916283469 A 20190222; US 51403006 A 20060830; US 81809910 A 20100617; US 82401410 A 20100625; US 87496510 A 20100902; ZA 200802765 A 20060830