EP 2399910 A4 20121017 - NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Title (en)
NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Title (de)
NEUE TRIAZINDERIVATE UND PHARMAZEUTISCHE ZUSAMMENSETZUNG, DIE DIESE ENTHÄLT
Title (fr)
NOUVEAU DÉRIVÉ DE TRIAZINE ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
Publication
Application
Priority
- JP 2010051920 W 20100210
- JP 2009031520 A 20090213
- JP 2009266903 A 20091125
Abstract (en)
[origin: EP2399910A1] The present invention provides a novel P2X 3 and/or P2X 2 / 3 receptor antago nist. A compound represented by the formula (I): wherein R a , R b and R c are, (a) R a and R b are taken together =Z; and R c is a group represented by R 1c ; or (b) R b and R c are taken together to form a bond; and R a is a group represented by -Y-R 1a ; R 1a and R 1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R 2 and R 3 are each independently substituted or unsubstituted aryl, etc.; R 4a and R 4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is -N(R 5 )-, etc.; R 5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; -Y- is -O-, etc.; =Z is =O, etc.; and n is an integer of 0 to 4.
IPC 8 full level
C07D 251/46 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61P 13/08 (2006.01); A61P 13/10 (2006.01); A61P 21/00 (2006.01); A61P 25/02 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 29/00 (2006.01); C07D 251/52 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP KR US)
A61K 31/53 (2013.01 - KR); A61P 7/00 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/08 (2017.12 - EP); A61P 13/10 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 251/16 (2013.01 - EP US); C07D 251/44 (2013.01 - EP US); C07D 251/46 (2013.01 - EP KR US); C07D 251/52 (2013.01 - EP US); C07D 401/06 (2013.01 - EP KR US); C07D 401/12 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/04 (2013.01 - EP US); C07D 403/06 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US); C07D 405/12 (2013.01 - EP US); C07D 409/06 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US)
Citation (search report)
- [X] EP 0547461 A1 19930623 - BAYER AG [DE]
- [XP] WO 2009058653 A1 20090507 - JANSSEN PHARMACEUTICA NV [BE], et al
- [X] EP 0005911 A1 19791212 - ICI LTD [GB]
- [X] US 4156002 A 19790522 - BROWN EDWARD D [GB], et al
- [X] WO 2006104715 A1 20061005 - JANSSEN PHARMACEUTICA NV [BE], et al
- [X] WO 2006104713 A1 20061005 - JANSSEN PHARMACEUTICA NV [BE], et al
- [X] WO 2005009980 A1 20050203 - NEUROGEN CORP [US], et al
- [X] L.SOMOGUY, Z.GYORGYDEAK, R.BOGNAR, CHEMISCHE BERICHTE, vol. 100, 1967, pages 1975 - 1982, XP009162515
- See references of WO 2010092966A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2399910 A1 20111228; EP 2399910 A4 20121017; EP 2399910 B1 20140402; AU 2010214356 A1 20110818; AU 2010214356 B2 20141030; BR PI1013642 A2 20160419; CA 2752269 A1 20100819; CA 2752269 C 20160830; CN 102395571 A 20120328; CN 102395571 B 20151216; ES 2474490 T3 20140709; JP 5692747 B2 20150401; JP WO2010092966 A1 20120816; KR 101422901 B1 20140723; KR 20110103470 A 20110920; MX 2011008362 A 20110824; PL 2399910 T3 20140930; PT 2399910 E 20140502; RU 2011137531 A 20130320; RU 2551845 C2 20150527; SG 173647 A1 20111028; TW 201033183 A 20100916; TW I457328 B 20141021; US 2011319414 A1 20111229; US 2016185736 A1 20160630; US 9150546 B2 20151006; US 9688643 B2 20170627; WO 2010092966 A1 20100819
DOCDB simple family (application)
EP 10741243 A 20100210; AU 2010214356 A 20100210; BR PI1013642 A 20100210; CA 2752269 A 20100210; CN 201080016705 A 20100210; ES 10741243 T 20100210; JP 2010051920 W 20100210; JP 2010550529 A 20100210; KR 20117018763 A 20100210; MX 2011008362 A 20100210; PL 10741243 T 20100210; PT 10741243 T 20100210; RU 2011137531 A 20100210; SG 2011057940 A 20100210; TW 99104558 A 20100212; US 201013201209 A 20100210; US 201514807724 A 20150723