EP 2404612 A1 20120111 - Diagnosis, prophylaxis and therapy of Alzheimer's disease and other neurodementing disorders
Title (en)
Diagnosis, prophylaxis and therapy of Alzheimer's disease and other neurodementing disorders
Title (de)
Diagnose, Prophylaxe und Therapie von Morbus Alzheimer und anderen Demenzerkrankungen
Title (fr)
Diagnostic, Prevention et traitment de la maladie d'Alzheimer et d'autres désordres neurologiques
Publication
Application
Priority
EP 10168867 A 20100708
Abstract (en)
The present invention relates to a polypeptide having an amino acid sequence comprising at least two substitutions of the glycine residues in one or more GXXXG motives in the amino acid sequence of the wild type A² peptide as depicted in SEQ ID NO:1. Furthermore the present invention relates to methods and a kit for diagnosing a neurodementing disease. The present invention further relates to the polypeptide for use as a medicament in human and veterinary medicine and as a diagnostic substance, in particular for use as a medicament for the prevention and for the diagnosis of the progression of Alzheimer's disease, Down's syndrome, Dementia with Lewy bodies, fronto-temporal dementia, misfolded protein/peptide related diseases, cerebral amyloid angiopathy, Prion disease and amyloidoses.
IPC 8 full level
A61K 38/17 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
C07K 14/4711 (2013.01); A61K 38/00 (2013.01)
Citation (applicant)
KAYED ET AL., SCIENCE, vol. 300, no. 5618, 18 April 2003 (2003-04-18), pages 486 - 9
Citation (search report)
- [A] EP 1944314 A1 20080716 - UNIV MARBURG PHILIPPS [DE], et al
- [A] WO 2004013172 A2 20040212 - INNOGENETICS NV [BE], et al
- [A] GRUDEN M A ET AL: "AUTOIMMUNE RESPONSES TO AMYLOID STRUCTURES OF ABETA(25-35) PEPTIDE AND HUMAN LYSOZYME IN THE SERUM OF PATIENTS WITH PROGRESSIVE ALZHEIMER'S DISEASE", DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, KARGER, BASEL, CH LNKD- DOI:10.1159/000079197, vol. 18, no. 2, 1 January 2004 (2004-01-01), pages 165 - 171, XP008056285, ISSN: 1420-8008
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
BA ME RS
DOCDB simple family (publication)
EP 2404612 A1 20120111; EP 2404612 A8 20120229; WO 2012004380 A1 20120112
DOCDB simple family (application)
EP 10168867 A 20100708; EP 2011061611 W 20110708