EP 2406281 B1 20160217 - BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
Title (en)
BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
Title (de)
VARIANTEN DES KNOCHENMORPHOGENETISCHEN PROTEINS 2 (BONE MORPHOGENETIC PROTEIN 2, BMP2) MIT REDUZIERTER BMP-ANTAGONISTISCHER EMPFINDLICHKEIT
Title (fr)
VARIANTS DE LA PROTÉINE MORPHOGÉNÉTIQUE OSSEUSE 2 (BMP2) AVEC UNE SENSIBILITÉ RÉDUITE AUX ANTAGONISTES DES BMP
Publication
Application
Priority
- EP 2010053103 W 20100311
- EP 09155049 A 20090312
- EP 10713149 A 20100311
Abstract (en)
[origin: WO2010103070A2] The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
IPC 8 full level
C07K 14/51 (2006.01); A61K 38/18 (2006.01)
CPC (source: EP US)
A61P 1/02 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); C07K 14/51 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010103070 A2 20100916; WO 2010103070 A3 20110113; AU 2010223268 A1 20111020; AU 2010223268 B2 20150423; CN 102369212 A 20120307; CN 102369212 B 20151216; EP 2406281 A2 20120118; EP 2406281 B1 20160217; JP 2012520066 A 20120906; JP 5749659 B2 20150715; US 2012058944 A1 20120308; US 8828937 B2 20140909
DOCDB simple family (application)
EP 2010053103 W 20100311; AU 2010223268 A 20100311; CN 201080011605 A 20100311; EP 10713149 A 20100311; JP 2011553455 A 20100311; US 201013255909 A 20100311