EP 2407450 A1 20120118 - Method for producing optically active diamine derivative
Title (en)
Method for producing optically active diamine derivative
Title (de)
Verfahren zur Herstellung eines optisch aktiven Diaminderivats
Title (fr)
Procédé de production d'un dérivé diamine optiquement actif
Publication
Application
Priority
- JP 2010053976 W 20100310
- JP 2009061708 A 20090313
Abstract (en)
The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a method for industrially producing a compound (1) or a compound (4), comprising: [Step 1]: adding a quaternary ammonium salt and a metal azide salt to water to prepare an aqueous solution of an azidification reagent complex comprising quaternary ammonium salt-metal azide salt, and subsequently dehydrating the aqueous solution using an aromatic hydrocarbon solvent to form a mixed solution of the azidification reagent complex comprising quaternary ammonium salt-metal azide salt and the aromatic hydrocarbon solvent with a water content of 0.2% or less; and [Step 2]: adding, to the mixed solution prepared in [Step 1], a compound (2) wherein L represents a leaving group.
IPC 8 full level
C07C 269/06 (2006.01); C07B 53/00 (2006.01); C07B 55/00 (2006.01); C07B 61/00 (2006.01); C07C 269/08 (2006.01); C07C 271/24 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP US)
C07B 53/00 (2013.01 - EP US); C07B 55/00 (2013.01 - EP US); C07C 247/14 (2013.01 - EP US); C07C 269/06 (2013.01 - EP US); C07C 269/08 (2013.01 - EP US); C07D 513/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2407450 A1 20120118; EP 2407450 A4 20120801; EP 2407450 B1 20150422; CN 102348680 A 20120208; CN 102348680 B 20141105; ES 2542237 T3 20150803; JP 5652879 B2 20150114; JP WO2010104106 A1 20120913; US 2012035369 A1 20120209; US 9175012 B2 20151103; WO 2010104106 A1 20100916
DOCDB simple family (application)
EP 10750859 A 20100310; CN 201080011257 A 20100310; ES 10750859 T 20100310; JP 2010053976 W 20100310; JP 2011503838 A 20100310; US 201113231081 A 20110913