EP 2407488 A2 20120118 - ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL USING CELL-PERMEABLE REPROGRAMMING TRANSCRIPTION FACTOR FOR CUSTOMIZED STEM CELL THERAPY
Title (en)
ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL USING CELL-PERMEABLE REPROGRAMMING TRANSCRIPTION FACTOR FOR CUSTOMIZED STEM CELL THERAPY
Title (de)
BESTIMMUNG VON INDUZIERTEN PLURIPOTENTEN STAMMZELLEN ANHAND EINES ZELLPERMEABLEN REPOGRAMMIERENDEN TRANSKRIPTIONSFAKTORS FÜR PERSONALISIERTE STAMMZELLENTHERAPIE
Title (fr)
ÉTABLISSEMENT DE CELLULE SOUCHE PLURIPOTENTE INDUITE À L'AIDE D'UN FACTEUR DE TRANSCRIPTION DE REPROGRAMMATION À PERMÉABILITÉ CELLULAIRE POUR UNE THÉRAPIE PAR CELLULES SOUCHES PERSONNALISÉES POUR UN PATIENT
Publication
Application
Priority
- KR 2010001559 W 20100312
- US 15946109 P 20090312
Abstract (en)
The present invention relates to a reprogramming transcription factor recombinant protein in which a macromolecule transduction domain (MTD) is fused to a reprogramming transcription factor to obtain cell permeability. The present invention also relates to a polynucleotide for coding said reprogramming transcription factor recombinant protein and to an expression vector of said cell-permeable reprogramming transcription factor recombinant protein. Treating a somatic cell with the cell-permeable reprogramming transcription factor recombinant protein induces the reprogramming of the stem cell-specific gene of the somatic cell, and thus can be effectively used in the establishment of an induced pluripotent stem cell (iPS cell) having characteristics similar to those of an embryonic stem cell in terms of morphology and genetics.
IPC 8 full level
C07K 19/00 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C12N 5/074 (2010.01); C12N 5/10 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01)
CPC (source: EP KR US)
C07K 14/4702 (2013.01 - EP US); C07K 19/00 (2013.01 - KR); C12N 5/10 (2013.01 - KR); C12N 15/62 (2013.01 - KR); C12N 15/63 (2013.01 - KR); C07K 2319/09 (2013.01 - EP US); C07K 2319/10 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2407488 A2 20120118; EP 2407488 A4 20130313; CN 102439045 A 20120502; KR 20120034595 A 20120412; US 2012095188 A1 20120419; WO 2010104357 A2 20100916; WO 2010104357 A3 20110303; WO 2010104357 A4 20110421
DOCDB simple family (application)
EP 10751048 A 20100312; CN 201080021034 A 20100312; KR 2010001559 W 20100312; KR 20117023922 A 20100312; US 201013263955 A 20100312