EP 2408778 A1 20120125 - N-[(6-AZA-BICYCLO[3.2.1]OCT-5-YL)-ARYL-METHYL]-HETEROBENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE OF SAME
Title (en)
N-[(6-AZA-BICYCLO[3.2.1]OCT-5-YL)-ARYL-METHYL]-HETEROBENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE OF SAME
Title (de)
N-[(6-AZABICYCLO[3.2.1]OCT-5-YL]ARYLMETHYL] HETEROBENZAMIDDERIVATE, DEREN HERSTELLUNG UND DEREN THERAPEUTISCHE VERWENDUNG
Title (fr)
DERIVES DE N-[(6-AZA-BICYCLO[3.2.1]OCT-5-YL)-ARYL-METHYL]-HETEROBENZAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
Publication
Application
Priority
- FR 2010050448 W 20100315
- FR 0901220 A 20090316
Abstract (en)
[origin: WO2010106270A1] The invention relates to a compound of the general formula (I), where: R is a hydrogen atom or a group selected from the (C1-C6)alkyl or (C3-C7)-cycloalkyl groups, optionally substituted by one or more groups independently selected from a halogen atom and the (C3-C7)-cycloalkyl, (C1-C6)alkyl, (C1-C6)alkoxy, and hydroxy groups; R1 is a phenyl group optionally substituted by one or more substituents independently selected from halogen atoms and the (C1- C6)alkyl, (C1-C6)alkoxy, halo-(C1C6)alkyl, hydroxy, halo-(C1-C6)alkoxy, (C1-C6)alkyl-thio, (C1-C6)alkyl-SO, and (C1-C6)alkyl-SO2 groups; R2 is one or more substituents selected from a hydrogen atom, halogen atoms, and the halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1C3)alkyl, phenyl, benzyl, (C1-C6)alkoxy, (C1-C6)alkyl-thio, (C1-C6))alkyl-SO, and (C1-C6)alkyl-SO2 groups; and Het is a heteroaryl group; wherein said compound is in the form of a base or an acid addition salt. The invention also relates to the therapeutic use thereof and to a method for synthesising same.
IPC 8 full level
C07D 487/08 (2006.01); A61K 31/403 (2006.01); A61K 31/55 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP KR US)
A61P 15/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/32 (2017.12 - EP); C07D 487/08 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2010106270A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
FR 2943059 A1 20100917; AR 075838 A1 20110427; AU 2010224721 A1 20111006; BR PI1009497 A2 20180313; CA 2755528 A1 20100923; CN 102356084 A 20120215; EP 2408778 A1 20120125; IL 215103 A0 20111229; JP 2012520346 A 20120906; KR 20120013325 A 20120214; MX 2011009746 A 20110929; RU 2011141760 A 20130427; SG 174432 A1 20111028; TW 201100431 A 20110101; US 2012029027 A1 20120202; UY 32496 A 20101029; WO 2010106270 A1 20100923
DOCDB simple family (application)
FR 0901220 A 20090316; AR P100100801 A 20100315; AU 2010224721 A 20100315; BR PI1009497 A 20100315; CA 2755528 A 20100315; CN 201080012152 A 20100315; EP 10715933 A 20100315; FR 2010050448 W 20100315; IL 21510311 A 20110912; JP 2012500293 A 20100315; KR 20117024140 A 20100315; MX 2011009746 A 20100315; RU 2011141760 A 20100315; SG 2011066842 A 20100315; TW 99107513 A 20100315; US 201013256834 A 20100315; UY 32496 A 20100316