EP 2413973 A1 20120208 - POLYMERIC CONJUGATES OF PACLITAXEL AND DOCETAXEL WITH PH-CONTROLLED RELEASING OF THE CANCEROSTATIC AGENT
Title (en)
POLYMERIC CONJUGATES OF PACLITAXEL AND DOCETAXEL WITH PH-CONTROLLED RELEASING OF THE CANCEROSTATIC AGENT
Title (de)
POLYMER-KONJUGATE VON PACLITAXEL UND DOCETAXEL MIT PH-KONTROLLIERTER FREISETZUNG DES KANZEROSTATISCHEN MITTELS
Title (fr)
CONJUGUÉS POLYMÈRE DE PACLITAXEL ET DE DOCÉTAXEL À LIBÉRATION CONTRÔLÉE EN PH D'UN AGENT CANCÉROSTATIQUE
Publication
Application
Priority
- CZ 2010000014 W 20100209
- CZ 200985 A 20090213
Abstract (en)
[origin: WO2010091650A1] The present invention describes a polymeric conjugate consisting of a derivative of a cytostatic agent selected from the group of taxanes, in particular paclitaxel (PTX), docetaxel (DTX) or larotaxel (LTX), and a polymeric carrier prepared on the basis of a linear or biodegradable grafted copolymer consisting of units of the basic copolymer N-(2-hydroxypropyl)methacroylamide (HPMA) and units containing methacryloylated hydrazones of amino acids or oligopeptides. The invention also deals with a method of preparation of the above mentioned polymeric conjugate, in which the polymeric carrier is subjected to polymer-analogous transformation of the carrier by reaction with an ester of the oxo acid and the cytostatic agent. The polymeric conjugate is used for the preparation of a medicament for treatment of tumour diseases.
IPC 8 full level
A61K 47/58 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/58 (2017.07); A61K 47/65 (2017.07); A61P 35/00 (2017.12)
Citation (search report)
See references of WO 2010091650A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010091650 A1 20100819; CZ 200985 A3 20100825; CZ 303072 B6 20120321; EA 022803 B1 20160331; EA 201190315 A1 20120530; EP 2413973 A1 20120208; UA 104187 C2 20140110
DOCDB simple family (application)
CZ 2010000014 W 20100209; CZ 200985 A 20090213; EA 201190315 A 20100209; EP 10716267 A 20100209; UA A201115172 A 20100209