Global Patent Index - EP 2416798 A4

EP 2416798 A4 20130109 - PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS (HPV) VACCINES

Title (en)

PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS (HPV) VACCINES

Title (de)

PAPILLOMAVIRUS-LIKE PARTIKEL (VLP) ALS BREITBANDIMPFSTOFFE GEGEN HUMANES PAPILLOMAVIRUS (HPV)

Title (fr)

PARTICULES RESSEMBLANT AU PAPILLOMAVIRUS (VLP) COMME VACCINS À LARGE SPECTRE CONTRE LE PAPILLOMAVIRUS HUMAIN (VPH)

Publication

EP 2416798 A4 20130109 (EN)

Application

EP 10762572 A 20100412

Priority

  • US 2010030757 W 20100412
  • US 16844509 P 20090410

Abstract (en)

[origin: WO2010118424A2] This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid protein, into which is inserted a surface-displayed peptide comprising a neutralizing epitope of a papillomavirus L2 protein. Vaccine compositions comprising the VLP are described, as well as methods for inducing an immune response (e.g., vaccinating) a subject against papilloma virus, using the VLP, and kits comprising the VLP, for carrying out a method of the invention.

IPC 8 full level

A61K 39/12 (2006.01); C07K 14/025 (2006.01)

CPC (source: CN EP US)

A61K 38/16 (2013.01 - CN EP US); A61K 39/12 (2013.01 - CN EP US); A61P 31/12 (2017.12 - EP); A61P 31/20 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); C12N 7/00 (2013.01 - CN); A61K 2039/5258 (2013.01 - CN EP US); A61K 2039/55505 (2013.01 - CN EP US); A61K 2039/55566 (2013.01 - CN EP US); A61K 2039/55572 (2013.01 - CN EP US); C07K 2319/40 (2013.01 - CN EP US); C12N 7/00 (2013.01 - EP US); C12N 2710/20023 (2013.01 - CN EP US); C12N 2710/20034 (2013.01 - CN EP US)

Citation (search report)

  • [XY] WO 2009001867 A1 20081231 - JAPAN HEALTH SCIENCE FOUND [JP], et al & US 2010183648 A1 20100722 - KANDA TADAHITO [JP], et al
  • [Y] WO 2007018049 A1 20070215 - JAPAN HEALTH SCIENCE FOUND [JP], et al
  • [XY] KAZUNARI KONDO ET AL: "You have full text access to this contentModification of human papillomavirus-like particle vaccine by insertion of the cross-reactive L2-epitopes", JOURNAL OF MEDICAL VIROLOGY, JOHN WILEY & SONS, INC, US, vol. 80, no. 5, 1 May 2008 (2008-05-01), pages 841 - 846, XP008126685, ISSN: 0146-6615, DOI: 10.1002/JMV.21124
  • [Y] VARSANI A ET AL: "CHIMERIC HUMAN PAPILLOMAVIRUS TYPE 16 (HPV-16) L1 PARTICLES PRESENTING THE COMMON NEUTRALIZING EPITOPE FOR THE L2 MINOR CAPSID PROTEIN OF HPV-6 AND HPV-16", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 77, no. 15, 1 August 2003 (2003-08-01), pages 8386 - 8393, XP009017129, ISSN: 0022-538X, DOI: 10.1128/JVI.77.15.8386-8393.2003
  • [Y] KONDO ET AL: "Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 358, no. 2, 25 January 2007 (2007-01-25), pages 266 - 272, XP005853978, ISSN: 0042-6822, DOI: 10.1016/J.VIROL.2006.08.037
  • [A] BISHOP B ET AL: "Crystal structures of four types of human papillomavirus L1 capsid proteins: Understanding the specificity of neutralizing monoclonal antibodies", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 282, no. 43, 26 October 2007 (2007-10-26), pages 31803 - 31811, XP002608877, ISSN: 0021-9258, [retrieved on 20070904], DOI: 10.1074/JBC.M706380200
  • See references of WO 2010118424A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010118424 A2 20101014; WO 2010118424 A3 20110526; BR PI1013895 A2 20160920; BR PI1013895 B1 20210803; CN 102458440 A 20120516; CN 107080833 A 20170822; DK 2416798 T3 20180108; EP 2416798 A2 20120215; EP 2416798 A4 20130109; EP 2416798 B1 20170920; ES 2653251 T3 20180206; HK 1242997 A1 20180706; US 10046026 B2 20180814; US 2012093821 A1 20120419; US 2016200774 A1 20160714; US 9149503 B2 20151006

DOCDB simple family (application)

US 2010030757 W 20100412; BR PI1013895 A 20100412; CN 201080025772 A 20100412; CN 201710195588 A 20100412; DK 10762572 T 20100412; EP 10762572 A 20100412; ES 10762572 T 20100412; HK 18102596 A 20180222; US 201013263563 A 20100412; US 201514875374 A 20151005