EP 2416807 A1 20120215 - NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES
Title (en)
NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES
Title (de)
NEUE STRATEGIEN FÜR VERBESSERTE KREBSIMPFSTOFFE
Title (fr)
NOUVELLES STRATÉGIES D'AMÉLIORATION DES VACCINS ANTICANCÉREUX
Publication
Application
Priority
- US 2010030045 W 20100406
- US 16829009 P 20090410
- US 54447609 A 20090820
Abstract (en)
[origin: WO2010117984A1] Methods and compositions for forming anti-cancer vaccine complexes are disclosed The vaccine complex comprises an antibody moiety that binds to dendritic cells, such as an ant?-CD74 antibody or antigen-binding fragment thereof, attached to an AD (anchoring domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, wherein two copies of the DDD moiety form a dimer that binds to the AD moiety, resulting in the formation of the vaccine complex The vaccine complex is capable of inducing an immune response against xenoantigen expressing cancer cells, such as CD13S sub neg CD20+ MM stem cells, and inducing apoptosis of and inhibiting the growth of or eliminating the cancer cells
IPC 8 full level
A61K 51/00 (2006.01); A61K 39/00 (2006.01); C12P 21/08 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP US)
A61K 39/001124 (2018.08 - EP US); C07K 16/00 (2013.01 - EP); C07K 16/2833 (2013.01 - EP); C07K 16/2863 (2013.01 - EP); C07K 16/2887 (2013.01 - EP); C07K 16/3007 (2013.01 - EP); C07K 16/44 (2013.01 - EP); A61K 2039/6031 (2013.01 - EP); A61K 2039/80 (2018.08 - EP US); C07K 2317/55 (2013.01 - EP); C07K 2317/77 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); C07K 2319/30 (2013.01 - EP); C07K 2319/70 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010117984 A1 20101014; EP 2416807 A1 20120215; EP 2416807 A4 20120613
DOCDB simple family (application)
US 2010030045 W 20100406; EP 10762283 A 20100406