EP 2418287 A2 20120215 - Nucleic acid amplification primers for PCR-based clonality studies of the TCR-beta gene
Title (en)
Nucleic acid amplification primers for PCR-based clonality studies of the TCR-beta gene
Title (de)
Primer für PCR-basierte Studien der Klonalität des TCR-beta Gens
Title (fr)
Amorces pour des études de la clonalité du gène TCR-beta basées sur PCR
Publication
Application
Previously filed application
PCT/NL03/00690 20031013 WO
Priority
- EP 03756746 A 20031013
- US 41777902 P 20021011
Abstract (en)
The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a V²-J² TCRB rearrangement, and optionally a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V»-J» IGL rearrangement, a D²-J² TCRB rearrangement, a V³-J³ TCRG rearrangement, a V´-J´ TCRD rearrangement, a D´-D´ TCRD rearrangement, a D´-J´ TCRD rearrangement, a V´-D´ TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-ICrH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP US)
C12Q 1/6883 (2013.01 - US); C12Q 1/6886 (2013.01 - EP US); C12Q 2600/112 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US); C12Q 2600/16 (2013.01 - EP US)
Citation (applicant)
- W. RYCHLICK, MOLECULAR BIOLOGY INSIGHTS
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