Global Patent Index - EP 2423177 A1

EP 2423177 A1 20120229 - Analogs of geranylgeranylacetone (GGA)

Title (en)

Analogs of geranylgeranylacetone (GGA)

Title (de)

Analoga von Geranylgeranylaceton

Title (fr)

Analogues du géranylgéranylacétone (GGA)

Publication

EP 2423177 A1 20120229 (EN)

Application

EP 10174055 A 20100825

Priority

EP 10174055 A 20100825

Abstract (en)

The invention relates to novel therapeutic compounds, more in particular to biologically active analogs of geranylgeranylacetone (GGA), and various use thereof. Provided is a compound of the general formula I

IPC 8 full level

C07C 45/71 (2006.01); A61K 31/10 (2006.01); A61K 31/121 (2006.01); A61K 31/15 (2006.01); C07C 49/203 (2006.01); C07C 49/217 (2006.01); C07C 49/227 (2006.01); C07C 251/36 (2006.01); C07C 251/38 (2006.01); C07C 317/08 (2006.01)

CPC (source: EP)

C07C 49/203 (2013.01); C07C 49/213 (2013.01); C07C 49/227 (2013.01); C07C 69/145 (2013.01); C07C 233/05 (2013.01); C07C 251/40 (2013.01); C07C 317/08 (2013.01)

Citation (applicant)

  • WO 2006062402 A2 20060615 - ZERNIKE BUSINESS SUPPORT B V [NL], et al
  • CARROLL, M. F.: "131. Addition of o,b-unsaturated alcohols to the active methylene group. Part I. The action of ethyl acetoacetate on linalool and geraniol", J. CHEM. SOC., 1940, pages 704 - 706
  • TSUJI, TETRAHEDRON LETTERS, vol. 21, no. 33, 1980, pages 3199 - 3202

Citation (search report)

  • [XY] US 4059641 A 19771122 - MISHIMA HIROSHI, et al
  • [XY] US 4169157 A 19790925 - KIJIMA SHIZUMASA, et al
  • [IDY] WO 2006062402 A2 20060615 - ZERNIKE BUSINESS SUPPORT B V [NL], et al
  • [XY] DOLENCE J M ET AL: "Synthesis of Analogs of Farnesyl Diphosphate", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 52, no. 1, 1 January 1996 (1996-01-01), pages 119 - 130, XP004104589, ISSN: 0040-4020, DOI: 10.1016/0040-4020(95)00909-R
  • [XY] CAMPS F ET AL: "Trifluoromethyl Analogs of Juvenile Hormones", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 34, 1 January 1978 (1978-01-01), pages 2179 - 2182, XP007916988, ISSN: 0040-4020
  • [XY] KEIJI MARUOKA ET AL: "Stabilization of Reactive Aldehydes by Complexation with Methylaluminum Bis( 2,6-diphenylphenoxide) and Their Synthetic Application", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 115, 1 January 1993 (1993-01-01), pages 3943 - 3949, XP007916989, ISSN: 0002-7863
  • [XY] PREPARATION OF: "Preparation of Modified Squalenes", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH; GB, vol. 77, 20 November 1955 (1955-11-20), pages 6073 - 6075, XP007916990, ISSN: 0368-1769
  • [XY] HUNT C ET AL: "The Photochemistry of 7,11-Dimethyldodeca-1,6,10-Trien-3-One", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 27, 1 January 1971 (1971-01-01), pages 1491 - 1497, XP007916991, ISSN: 0040-4020
  • [A] CARROLL M F: "Addition of alpha beta-unsaturated alcohols to the active methylene group. Part III. Scope and mechanism of the reaction", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1941 (1941-01-01), pages 507 - 511, XP009144055, ISSN: 0368-1769, DOI: 10.1039/JR9410000507
  • [A] GIANFRANCO PALA ET AL: "Terpene Compounds as Drugs. III. Terpenylketoximes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 10, no. 5, 1 September 1967 (1967-09-01), pages 980, XP007916992, ISSN: 0022-2623, DOI: 10.1021/JM00317A066
  • [A] BIANCA J J M BRUNDEL ET AL: "Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 99, 10 January 2006 (2006-01-10), pages 1394 - 1402, XP007916993, ISSN: 0009-7330, [retrieved on 20061116], DOI: 10.1161/01.RES.0000252323.83137.FE
  • [A] MASAO SAKABE1 ET AL: "Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia", CARDIOVASCULAR RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 78, 1 January 2008 (2008-01-01), pages 63 - 70, XP007916994, ISSN: 0008-6363, [retrieved on 20080131], DOI: 10.1093/CVR/CVN019

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

Designated extension state (EPC)

BA ME RS

DOCDB simple family (publication)

EP 2423177 A1 20120229; WO 2012026813 A2 20120301; WO 2012026813 A3 20120531

DOCDB simple family (application)

EP 10174055 A 20100825; NL 2011050576 W 20110825