EP 2427453 A1 20120314 - SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
Title (en)
SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
Title (de)
SUBSTITUIERTE INDAZOL- UND AZAINDAZOL-DERIVATE ALS GAMMA-SECRETASE-MODULATOREN
Title (fr)
DÉRIVÉS D'INDAZOLE ET D'AZA-INDAZOLE SUBSTITUÉS EN TANT QUE MODULATEURS DE LA GAMMA SECRÉTASE
Publication
Application
Priority
- EP 2010056074 W 20100505
- EP 09159615 A 20090507
- EP 10719325 A 20100505
Abstract (en)
[origin: WO2010145883A1] The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I), wherein R1, R2, R3, R4, Y, A1, A2, A3, A4, X1, X2, X3 and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
IPC 8 full level
C07D 403/12 (2006.01); A61K 31/416 (2006.01); A61P 25/28 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR US)
A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 403/12 (2013.01 - EP KR US); C07D 403/14 (2013.01 - EP KR US); C07D 413/12 (2013.01 - EP KR US); C07D 413/14 (2013.01 - EP US); C07D 417/12 (2013.01 - EP KR US); C07D 471/04 (2013.01 - EP US)
Citation (search report)
See references of WO 2010145883A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
BA ME RS
DOCDB simple family (publication)
WO 2010145883 A1 20101223; AR 076850 A1 20110713; AU 2010262036 A1 20110922; AU 2010262036 B2 20141030; BR PI1011190 A2 20160315; BR PI1011190 A8 20161116; CA 2755467 A1 20101223; CN 102439005 A 20120502; CN 102439005 B 20150722; EA 019702 B1 20140530; EA 201171363 A1 20120430; EP 2427453 A1 20120314; EP 2427453 B1 20130717; ES 2431619 T3 20131127; IL 216113 A0 20120131; IL 216113 A 20150226; JP 2012526078 A 20121025; JP 5559309 B2 20140723; KR 20120024555 A 20120314; MX 2011011753 A 20111129; MY 152998 A 20141231; NZ 596843 A 20121221; SG 175317 A1 20111128; TW 201105658 A 20110216; TW I461419 B 20141121; UA 105377 C2 20140512; US 2012095036 A1 20120419; US 8835482 B2 20140916; ZA 201108117 B 20150624
DOCDB simple family (application)
EP 2010056074 W 20100505; AR P100101549 A 20100506; AU 2010262036 A 20100505; BR PI1011190 A 20100505; CA 2755467 A 20100505; CN 201080020131 A 20100505; EA 201171363 A 20100505; EP 10719325 A 20100505; ES 10719325 T 20100505; IL 21611311 A 20111103; JP 2012509024 A 20100505; KR 20117024948 A 20100505; MX 2011011753 A 20100505; MY PI2011005324 A 20100505; NZ 59684310 A 20100505; SG 2011077518 A 20100505; TW 99114456 A 20100506; UA A201110540 A 20100505; US 201013263860 A 20100505; ZA 201108117 A 20111104