EP 2428203 A1 20120314 - A NANO-EMULSION INJECTION OF VINCA ALKALOIDS AND THE PREPARATION METHOD THEREOF
Title (en)
A NANO-EMULSION INJECTION OF VINCA ALKALOIDS AND THE PREPARATION METHOD THEREOF
Title (de)
NANOEMULSIONSINJEKTION VON VINCA-ALKALOIDEN UND HERSTELLUNGSVERFAHREN DAFÜR
Title (fr)
NANOÉMULSION INJECTABLE DE VINCA-ALCALOÏDES ET SON PROCÉDÉ DE PRÉPARATION
Publication
Application
Priority
- CN 2009075409 W 20091208
- CN 200910050689 A 20090506
Abstract (en)
A nano-emulsion injection of Vinca alkaloids and its preparation method are disclosed. The injection is an oil-in-water emulsion injection comprising Vinca alkaloids or their salts, injectable oil, surfactant(s) and injectable water, wherein the average diameter of the droplets of the emulsion is less than 100 nm and the pH of the emulsion is 7-9. The preparation method comprises the steps of preparing the oil phase and the aqueous phase respectively, homogeneously mixing the oil phase and the aqueous phase with high speed, adding the active ingredient, adjusting the pH to 7-9, adding water to constant volume, and homogenizing the emulsion till the average diameter of the droplets being less than 100 nm. The alternative method comprises the steps of homogeneously mixing the oil phase and the aqueous phase, homogenizing the obtained emulsion under high pressure till the average diameter of the droplets being less than 100 nm, adding the active ingredient, adjusting the pH to 7-9, stirring, and adding water to constant volume.
IPC 8 full level
A61K 9/107 (2006.01); A61K 31/475 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP US); A61K 9/1075 (2013.01 - EP US); A61K 31/475 (2013.01 - EP US); A61P 35/00 (2017.12 - EP)
Citation (search report)
See references of WO 2010127541A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2428203 A1 20120314; CN 101879138 A 20101110; CN 102159187 A 20110817; CN 102159187 B 20121010; US 2012045489 A1 20120223; WO 2010127541 A1 20101111
DOCDB simple family (application)
EP 09844293 A 20091208; CN 2009075409 W 20091208; CN 200910050689 A 20090506; CN 200980137112 A 20091208; US 200913318548 A 20091208