Global Patent Index - EP 2438165 A1

EP 2438165 A1 20120411 - COMPOSITIONS OF PROTHROMBINE COMPLEX

Title (en)

COMPOSITIONS OF PROTHROMBINE COMPLEX

Title (de)

PROTHROMBINKOMPLEX ZUSAMMENSETZUNGEN

Title (fr)

COMPOSITION DE COMPLEXE PROTHROMBIQUE

Publication

EP 2438165 A1 20120411 (FR)

Application

EP 10728330 A 20100604

Priority

  • IB 2010052497 W 20100604
  • FR 0902723 A 20090605

Abstract (en)

[origin: WO2010140140A1] The present invention relates to a method for preparing a composition or a concentrate of a prothrombic complex that includes the II, VII, IX and X coagulation factors, wherein said method includes the steps of providing a supernatant of a plasma cryoprecipitate, applying said supernatant on an anion-exchange resin in order to produce an eluate containing said complex and proteins having a high molecular weight, and applying said eluate on a hydroxyapatite column in order to produce a second eluate containing said complex. The invention also relates to a composition that can be produced by said method.

IPC 8 full level

C12N 9/64 (2006.01); C12N 9/74 (2006.01)

CPC (source: EP KR US)

A61P 7/04 (2017.12 - EP); C07K 1/14 (2013.01 - KR); C07K 14/745 (2013.01 - KR); C12N 7/04 (2013.01 - KR); C12N 9/6429 (2013.01 - EP US); C12N 9/6432 (2013.01 - EP US); C12N 9/6437 (2013.01 - EP US); C12N 9/644 (2013.01 - EP US); C12N 9/6464 (2013.01 - EP US); C12N 9/647 (2013.01 - EP US); C12Q 1/56 (2013.01 - KR); C12Y 304/21005 (2013.01 - EP US); C12Y 304/21006 (2013.01 - EP US); C12Y 304/21021 (2013.01 - EP US); C12Y 304/21022 (2013.01 - EP US); C12Y 304/21069 (2013.01 - EP US)

Citation (search report)

See references of WO 2010140140A1

Citation (examination)

  • EP 0346241 A1 19891213 - FOND NAT TRANSFUSION SANGUINE [FR]
  • JOSIC D ET AL: "Manufcturing of a Prothrombin Complex Concentrate Aiming at Low Thrombogenicity", THROMBOSIS RESEARCH, TARRYTOWN, NY, US, vol. 100, 1 January 2000 (2000-01-01), pages 433 - 441, XP003028450, ISSN: 0049-3848
  • CSL BEHRING GMBH: "PUBLIC ASSESSMENT REPORT BERIPLEX P/N 250 BERIPLEX P/N 500 HUMAN PROTHROMBIN COMPLEX DE/H/0477/001-002/MR APPLICANT: CSL BEHRING GMBH", 11 January 2008 (2008-01-11), pages 1 - 34, XP055285221, Retrieved from the Internet <URL:http://portal.dimdi.de/amispb/doc/pei/Web/2600004-paren-20080111.pdf> [retrieved on 20160701]
  • S CHANDRA ET AL: "Prothrombin Complex Concentrates for Clinical Use", VOX SANG., vol. 41, 1 January 1981 (1981-01-01), pages 257 - 273, XP055572119
  • JOSIC D ET AL: "Preparation of vitamin K-dependent proteins, such as clotting factors II, VII, IX and X and clotting inhibitor Protein C", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATI, ELSEVIER, AMSTERDAM, NL, vol. 790, no. 1-2, 25 June 2003 (2003-06-25), pages 183 - 197, XP004426799, ISSN: 1570-0232, DOI: 10.1016/S1570-0232(03)00082-5

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010140140 A1 20101209; AU 2010255377 A1 20111215; BR PI1009641 A2 20150818; CA 2764584 A1 20101209; CN 102459583 A 20120516; EP 2438165 A1 20120411; FR 2946348 A1 20101210; FR 2946348 B1 20110805; IL 216395 A0 20120131; JP 2012528850 A 20121115; KR 20120047216 A 20120511; US 2012087907 A1 20120412

DOCDB simple family (application)

IB 2010052497 W 20100604; AU 2010255377 A 20100604; BR PI1009641 A 20100604; CA 2764584 A 20100604; CN 201080025034 A 20100604; EP 10728330 A 20100604; FR 0902723 A 20090605; IL 21639511 A 20111116; JP 2012513730 A 20100604; KR 20117031284 A 20100604; US 201013376316 A 20100604