EP 2439212 B1 20161221 - Improved fibronectin-based binding molecules and uses thereof
Title (en)
Improved fibronectin-based binding molecules and uses thereof
Title (de)
Verbesserte Bindemoleküle auf Fibronectin-Basis und ihre Verwendung
Title (fr)
Molécules de liaison améliorées à base de fibronectine et utilisations associées
Publication
Application
Priority
- EP 09738252 A 20090504
- US 5014208 P 20080502
Abstract (en)
[origin: WO2009133208A1] The invention provides f?bronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecif?c Fn3 -based binding molecules that bind to two or more targets simultaneously. The Fn3 -based binding molecules of the invention can also be linked together to form multispecif?c Fn3-based binding molecules, and/or can be conjugated to a non-Fn3 moiety, such as, Human Serum Albumin (HSA), for improved half life and stability. The invention also provides methods for generating, screening and using Fn3 -based binding molecules in a variety of therapeutic and diagnostic applications.
IPC 8 full level
C07K 14/78 (2006.01); C07K 16/00 (2006.01)
CPC (source: EP US)
A61K 47/62 (2017.07 - EP US); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); C07K 14/78 (2013.01 - EP US); C07K 16/005 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); G01N 33/6845 (2013.01 - US); A61K 38/00 (2013.01 - EP US); C07K 2317/31 (2013.01 - EP US); C07K 2318/20 (2013.01 - EP US); C07K 2319/31 (2013.01 - EP US); C07K 2319/70 (2013.01 - EP US); G01N 2333/78 (2013.01 - US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009133208 A1 20091105; AU 2009242038 A1 20091105; AU 2009242038 B2 20130530; BR PI0913007 A2 20190924; CA 2723277 A1 20091105; CN 102076713 A 20110525; CN 102076713 B 20150325; EA 201001734 A1 20111031; EP 2274331 A1 20110119; EP 2274331 B1 20131106; EP 2383292 A1 20111102; EP 2439212 A1 20120411; EP 2439212 B1 20161221; EP 3173424 A1 20170531; ES 2445695 T3 20140304; ES 2620285 T3 20170628; JP 2011522517 A 20110804; JP 2017060481 A 20170330; JP 2018118978 A 20180802; JP 6192891 B2 20170906; KR 20110021832 A 20110304; MX 2010011957 A 20110304; PL 2274331 T3 20140430; PL 2439212 T3 20170630; PT 2274331 E 20140227; PT 2439212 T 20170329; US 2011038866 A1 20110217; US 2016376345 A1 20161229; US 2018127485 A1 20180510; US 9296810 B2 20160329
DOCDB simple family (application)
EP 2009055365 W 20090504; AU 2009242038 A 20090504; BR PI0913007 A 20090504; CA 2723277 A 20090504; CN 200980125313 A 20090504; EA 201001734 A 20090504; EP 09738252 A 20090504; EP 11153773 A 20090504; EP 11191379 A 20090504; EP 16202193 A 20090504; ES 09738252 T 20090504; ES 11191379 T 20090504; JP 2011506738 A 20090504; JP 2016208951 A 20161025; JP 2018037151 A 20180302; KR 20107026992 A 20090504; MX 2010011957 A 20090504; PL 09738252 T 20090504; PL 11191379 T 20090504; PT 09738252 T 20090504; PT 11191379 T 20090504; US 201514729718 A 20150603; US 201715813827 A 20171115; US 98949409 A 20090504