Global Patent Index - EP 2440232 B1

EP 2440232 B1 20180228 - GLYCOMACROPEPTIDE MEDICAL FOODS FOR NUTRITIONAL MANAGEMENT OF PHENYLKETONURIA AND OTHER METABOLIC DISORDERS

Title (en)

GLYCOMACROPEPTIDE MEDICAL FOODS FOR NUTRITIONAL MANAGEMENT OF PHENYLKETONURIA AND OTHER METABOLIC DISORDERS

Title (de)

MEDIZINISCHE NAHRUNGSMITTEL ENTHALTEND GLYKOMAKROPEPTIDE ZUR BEHANDLUNG DER PHENYLKETONURIE UND ANDEREN STOFFWECHSELSTÖRUNGEN

Title (fr)

ALIMENTS MÉDICAUX À BASE DE GLYCOMACROPEPTIDE POUR LA GESTION NUTRITIONNELLE D'UNE PHÉNYLCÉTONURIE ET AUTRES TROUBLES MÉTABOLIQUES

Publication

EP 2440232 B1 20180228 (EN)

Application

EP 10724977 A 20100611

Priority

  • US 2010038340 W 20100611
  • US 18669009 P 20090612

Abstract (en)

[origin: US2010317597A1] Medical foods containing glycomacroprotein and additional supplemented amounts of arginine, leucine, and optionally other amino acids, such as tyrosine, are disclosed. The medical foods can be used to provide the complete protein requirements for patients having metabolic disorders such as phenylketonuria.

IPC 8 full level

A23L 33/00 (2016.01); A61K 38/17 (2006.01); A61P 3/02 (2006.01)

CPC (source: CN EP US)

A23L 33/17 (2016.07 - EP US); A61K 38/018 (2013.01 - CN EP US); A61P 3/00 (2017.12 - EP); A61P 3/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP)

Citation (opposition)

Opponent : N.V. Nutricia

  • WO 2006044188 A1 20060427 - BRISTOL MYERS SQUIBB CO [US], et al
  • WO 9808402 A1 19980305 - NESTLE SA [CH], et al
  • NEY D.M. ET AL.: "Nutritional management of PKU with glycomacropeptide from cheese whey", NIH PUBLIC ACCESS AUTHOR MANUSCRIPT, vol. 32, no. 1, 29 October 2008 (2008-10-29), pages 1 - 13, XP055552536
  • VAN CALCAR ET AL.: "Improved nutritional management of phenylketonuria by using a diet containing glycomacropeptide compared with amino acids", AM J CLIN NUTR, vol. 89, 25 February 2009 (2009-02-25), pages 1068 - 1077, XP009138546
  • MACLEOD EL ET AL.: "Breakfast with glycomacropeptide compared with amino acids suppresses plasma ghrelin levels in individuals with phenylketoniuria", MOL GEN METAB, April 2010 (2010-04-01), pages 303 - 308, XP027143049
  • ETZEL MR.: "Process for isolating glycomacropeptide from diary products with a phenylalanine impurity of 0.5%w/w.", J. NUTR., vol. 134, 2004, pages 996S - 1002S, XP002499258
  • "SHS XPhe Maxamum Powered Medical Food", INNOVA MARKET INSIGHTS, August 2007 (2007-08-01), XP055552559
  • AHRING ET AL.: "Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers , Including Plasma Phe Levels", JOURNAL OF NUTRITION AND METABOLISM, vol. 2018, 2018, pages 1 - 11, XP055552565

Opponent : Regina Neuefeind

  • PKUIL: "2016 Annual Meeting Follow Up", ILLINOIS PKU PRESS SPRING 2017, 2017, pages 1 - 24, XP055552266, Retrieved from the Internet <URL:http://www.pkuil.org/wp-content/uploads/2014/12/PKU-Press-Spring-2017.pdf>
  • ANONYMOUS: "From Architect To PKU Expert: David Paolella Shares Cambrooke's Evolution", CAMBROOKE THERAPEUTICS, 2007, pages 1 - 6, XP055552272, Retrieved from the Internet <URL:https://www.cambrooke.com/blog/2017/11/from-architect-to-pku-expert-david-paolella-shares-cambrookes-evolution>
  • "Glyactin Bettermilk 15 original", CAMBROOKE THERAPEUTICS, 3 November 2015 (2015-11-03), XP055552425
  • "Humana Special Phelics 1,3,4,5", March 2005 (2005-03-01), XP055552430
  • NEY ET AL.: "Dietary Glycomacropeptide Supports Growth and Reduces the Concentrations of Phenylalanine in Plasma and Brain in a Murine Model of Phenylketonuria", J NUTR, vol. 138, 2008, pages 316 - 322, XP055552485
  • LIM ET AL.: "Acceptable low-phenylalanine foods and beverages can be made with glycomacropeptide from cheese whey for individuals with PKU", MOL GENET METAB, vol. 92, 2007, pages 176 - 178, XP022231851
  • NEY ET AL.: "Nutritional management of PKU with glycomacropeptide from cheese whey", J INHERIT METAB DIS, vol. 32, 2009, pages 32 - 39, XP019671031
  • MACLEOD ET AL.: "Breakfast with glycomacropeptide compared with amino acids suppresses plasma ghrelin levels in individuals with phenylketonuria", MOL GENET METAB, vol. 100, 2010, pages 303 - 308, XP027143049
  • VAN CALCAR ET AL.: "Improved nutritional management of phenylketonuria by using a diet containing glycomacropeptide compared with amino acids", AM J CLIN NUTR, vol. 89, 2009, pages 1068 - 1077, XP009138546
  • MACLEOD ET AL.: "Nutritional Management of Phenylketonuria", ANN NESTLE [ENGL), vol. 68, 2010, pages 58 - 69, XP055170206
  • LACLAIR ET AL.: "Purification and Use of Glycomacropeptide for Nutritional Management of Phenylketonuria", J FOOD SCI, vol. 74, no. 4, 2009, pages E199 - E206, XP009138545
  • "Protein and amino acid requirements in human nutrition", WHO TECHNICAL REPORT SERIES 935, 2007, pages 149 - 150, XP055552514
  • "Präparate dür die klinische Diätetik", SHS, 1 March 2000 (2000-03-01), pages 6 - 7,16-17,24-25, XP055552523
  • "Inborn Errors of Metabolisn Product Compendium", VITAFLO, August 2009 (2009-08-01), pages 6 - 10, XP055552528

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

US 2010317597 A1 20101216; US 8604168 B2 20131210; AU 2010259975 A1 20111222; AU 2010259975 B2 20141023; BR PI1013089 A2 20160405; CA 2764571 A1 20101216; CA 2764571 C 20181218; CL 2011003120 A1 20120525; CN 102481338 A 20120530; CN 106983854 A 20170728; DK 2440232 T3 20180430; EP 2440232 A1 20120418; EP 2440232 B1 20180228; ES 2669094 T3 20180524; JP 2012530067 A 20121129; MX 2011013126 A 20120213; NZ 596902 A 20130927; PT 2440232 T 20180323; US 10258074 B2 20190416; US 2013196024 A1 20130801; US 2014248414 A1 20140904; WO 2010144821 A1 20101216

DOCDB simple family (application)

US 81398810 A 20100611; AU 2010259975 A 20100611; BR PI1013089 A 20100611; CA 2764571 A 20100611; CL 2011003120 A 20111207; CN 201080036768 A 20100611; CN 201710196756 A 20100611; DK 10724977 T 20100611; EP 10724977 A 20100611; ES 10724977 T 20100611; JP 2012515187 A 20100611; MX 2011013126 A 20100611; NZ 59690210 A 20100611; PT 10724977 T 20100611; US 2010038340 W 20100611; US 201313795125 A 20130312; US 201414274253 A 20140509