Global Patent Index - EP 2445917 A4

EP 2445917 A4 20130102 - PHOTOLABILE COMPOUNDS

Title (en)

PHOTOLABILE COMPOUNDS

Title (de)

LICHTLABILE VERBINDUNGEN

Title (fr)

COMPOSES PHOTOLABILES

Publication

EP 2445917 A4 20130102 (EN)

Application

EP 10792793 A 20100628

Priority

  • US 2010040220 W 20100628
  • US 22092209 P 20090626

Abstract (en)

[origin: WO2010151879A1] The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule.

IPC 8 full level

C07F 1/00 (2006.01)

CPC (source: EP)

A61P 7/00 (2017.12); A61P 25/00 (2017.12); A61P 35/00 (2017.12); C07F 15/0053 (2013.01)

Citation (search report)

  • [XI] US 2008176940 A1 20080724 - ETCHENIQUE ROBERTO [AR], et al
  • [A] US 6750357 B1 20040615 - CHIARELLO RONALD H [US], et al
  • [XA] LEONARDO ZAYAT ET AL: "A New Strategy for Neurochemical Photodelivery: Metal-Ligand Heterolytic Cleavage", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, no. 4, 1 January 2003 (2003-01-01), pages 882 - 883, XP055044534, ISSN: 0002-7863, DOI: 10.1021/ja0278943
  • [XA] LEONARDO ZAYAT ET AL: "Ruthenium(II) Bipyridyl Complexes as Photolabile Caging Groups for Amines", INORGANIC CHEMISTRY, vol. 45, no. 4, 1 February 2006 (2006-02-01), pages 1728 - 1731, XP055044535, ISSN: 0020-1669, DOI: 10.1021/ic0512983
  • [XA] MARCELO SALIERNO ET AL: "Caged Amino Acids for Visible-Light Photodelivery", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 2008, no. 7, 1 March 2008 (2008-03-01), pages 1125 - 1128, XP055044538, ISSN: 1434-1948, DOI: 10.1002/ejic.200700963
  • [A] LEBON ET AL: "X-ray structure, redox and spectroscopic properties of ruthenium phosphine complexes [Ru(tpy)(bpy)(PPh3)]<2+> and [Ru(tpy)(bpy)(PCy3)]<2+>", INORGANICA CHIMICA ACTA, ELSEVIER BV, NL, vol. 360, no. 3, 21 January 2007 (2007-01-21), pages 1235 - 1239, XP005855507, ISSN: 0020-1693, DOI: 10.1016/J.ICA.2006.08.053
  • [XA] NESTOR E. KATZ ET AL: "4-Cyanopyridine-bridged binuclear and trinuclear complexes of ruthenium and iron", INORGANIC CHEMISTRY, vol. 27, no. 10, 1 May 1988 (1988-05-01), pages 1687 - 1694, XP055044556, ISSN: 0020-1669, DOI: 10.1021/ic00283a006
  • [A] CAROL A. BESSEL ET AL: "Steric ligand effects of six bidentate bipyridyl ligands", INORGANIC CHEMISTRY, vol. 32, no. 25, 1 December 1993 (1993-12-01), pages 5779 - 5784, XP055044559, ISSN: 0020-1669, DOI: 10.1021/ic00077a021
  • [A] MARY E. MARMION ET AL: "Ruthenium(IV)-oxo complexes: the novel utilization of tertiary pnictogen ligands", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 110, no. 5, 1 March 1988 (1988-03-01), pages 1472 - 1480, XP055044561, ISSN: 0002-7863, DOI: 10.1021/ja00213a019
  • See references of WO 2010151879A1

Citation (examination)

JERRY L. WALSH ET AL: "Trans isomers of ruthenium(II) complexes containing two bipyridine ligands", INORGANIC CHEMISTRY, vol. 21, no. 1, 1 January 1982 (1982-01-01), EASTON, US, pages 329 - 332, XP055260085, ISSN: 0020-1669, DOI: 10.1021/ic00131a060

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010151879 A1 20101229; WO 2010151879 A9 20110324; EP 2445917 A1 20120502; EP 2445917 A4 20130102; JP 2012531443 A 20121210; JP 2016041746 A 20160331; JP 5902618 B2 20160413

DOCDB simple family (application)

US 2010040220 W 20100628; EP 10792793 A 20100628; JP 2012517826 A 20100628; JP 2015229061 A 20151124