EP 2447255 A1 20120502 - Process for the synthesis of cyclic carbamates
Title (en)
Process for the synthesis of cyclic carbamates
Title (de)
Verfahren zur Synthese von zyklischen Carbamaten
Title (fr)
Processus de synthèse de carbamates cycliques
Publication
Application
Priority
EP 10013631 A 20101014
Abstract (en)
The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C 2-5 -alkyl C 2-5 -carboxylates and mixtures of at least one C 2-5 -alkyl C 2-5 -carboxylate with at least one C 5-8 -alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.
IPC 8 full level
C07D 265/18 (2006.01)
CPC (source: EP US)
C07D 265/18 (2013.01 - EP US)
Citation (applicant)
- WO 9827073 A1 19980625 - DU PONT [US]
- WO 9851676 A1 19981119 - MERCK & CO INC [US], et al
- WO 9961026 A1 19991202 - MERCK & CO INC [US], et al
- WO 9520389 A1 19950803 - MERCK & CO INC [US]
- WO 9637457 A1 19961128 - MERCK & CO INC [US]
- WO 9830543 A1 19980716 - MERCK & CO INC [US], et al
- WO 9830540 A1 19980716 - MERCK & CO INC [US], et al
- JIANG ET AL., DISCLOSED IN TETRAHEDRON LETT., vol. 43, 2002, pages 8323 - 8325
- J ORG. CHEM., vol. 6, 2002, pages 9449 - 9451
Citation (search report)
- [AD] WO 9827073 A1 19980625 - DU PONT [US]
- [A] US 2006047115 A1 20060302 - VEMISHETTI PURUSHOTHAM [US], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 2447255 A1 20120502; BR 112013009178 A2 20160726; BR 112013009178 A8 20171219; CN 103249725 A 20130814; CN 103249725 B 20160120; EA 201390536 A1 20130930; EP 2627643 A1 20130821; EP 2627643 B1 20161123; ES 2613357 T3 20170524; HK 1183871 A1 20140110; IL 225746 A0 20130627; IL 225746 A 20161229; TW 201231460 A 20120801; TW I525081 B 20160311; US 2013217875 A1 20130822; US 8957204 B2 20150217; WO 2012048884 A1 20120419; ZA 201303008 B 20140528
DOCDB simple family (application)
EP 10013631 A 20101014; BR 112013009178 A 20111014; CN 201180059378 A 20111014; EA 201390536 A 20111014; EP 11773190 A 20111014; EP 2011005161 W 20111014; ES 11773190 T 20111014; HK 13111349 A 20131008; IL 22574613 A 20130414; TW 100137460 A 20111014; US 201113879258 A 20111014; ZA 201303008 A 20130424