Global Patent Index - EP 2448577 B1

EP 2448577 B1 20160914 - COMPOSITIONS CONTAINING BERBERINE OR ANALOGS THEREOF FOR TREATING ROSACEA OR RED FACE RELATED SKIN DISORDERS

Title (en)

COMPOSITIONS CONTAINING BERBERINE OR ANALOGS THEREOF FOR TREATING ROSACEA OR RED FACE RELATED SKIN DISORDERS

Title (de)

ZUSAMMENSETZUNGEN MIT BERBERIN ODER ANALOGEN DAVON ZUR BEHANDLUNG VON MIT ROSACEA ODER ANDEREN GESICHTSRÖTUNGEN ZUSAMMENHÄNGENDEN HAUTERKRANKUNGEN

Title (fr)

COMPOSITIONS CONTENANT DE LA BERBÉRINE OU DES ANALOGUES DE CELLE-CI POUR TRAITER L ACNÉ ROSACÉE OU DES TROUBLES CUTANÉS ASSOCIÉS À UNE ROUGEUR FACIALE

Publication

EP 2448577 B1 20160914 (EN)

Application

EP 10793513 A 20100630

Priority

  • CN 2010000983 W 20100630
  • US 22172509 P 20090630

Abstract (en)

[origin: WO2011000218A1] The present invention discloses topical pharmaceutical formulations of berberine and its biologically equivalent analogues, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also discloses methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogues, such as palmatine.

IPC 8 full level

A61K 31/4375 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/08 (2006.01); A61K 45/06 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 17/08 (2006.01)

CPC (source: CN EP KR RU US)

A61K 9/0014 (2013.01 - CN EP KR RU US); A61K 9/06 (2013.01 - KR); A61K 31/4375 (2013.01 - CN EP KR RU US); A61K 45/06 (2013.01 - EP KR RU US); A61K 47/10 (2013.01 - RU); A61P 17/00 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 17/08 (2018.01 - EP); A61P 17/10 (2018.01 - EP); A61P 19/04 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/10 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61K 2121/00 (2013.01 - KR)

Citation (examination)

  • REUTER JULIANE ET AL: "Botanicals in dermatology: an evidence-based review.", AMERICAN JOURNAL OF CLINICAL DERMATOLOGY 2010, vol. 11, no. 4, 2010, pages 247 - 267, ISSN: 1175-0561
  • LÍVIA SLOBODNÍKOVÁ ET AL: "Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids", vol. 18, no. 8, 1 August 2004 (2004-08-01), pages 674 - 676, XP008158021, ISSN: 0951-418X, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1002/ptr.1517/pdf> [retrieved on 20041008], DOI: 10.1002/PTR.1517
  • JU QIANG ET AL: "In vitro effects of the traditional chinese medicine, berberine, matrine and baicalin, on the proliferation and lipid synthesis of immortalized human sebocyte SZ95", ZHONGHUA PIFUKE ZAZHI - CHINESE JOURNAL OF DERMATOLOGY, ZHONGGUO YIXUE KEXUEYUAN PIFUBING YANJIUSUO, NANJING, CN, vol. 38, no. 11, 1 November 2005 (2005-11-01), pages 662 - 664, XP008158075, ISSN: 0412-4030
  • SEKI T ET AL: "Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands.", SKIN PHARMACOLOGY : THE OFFICIAL JOURNAL OF THE SKIN PHARMACOLOGY SOCIETY 1993, vol. 6, no. 1, 1993, pages 56 - 60, XP008176201, ISSN: 1011-0283

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2011000218 A1 20110106; AU 2010268647 A1 20120209; AU 2010268647 B2 20150115; BR PI1012128 A2 20160329; CA 2766834 A1 20110106; CA 2766834 C 20170425; CN 102481290 A 20120530; CN 105534978 A 20160504; EP 2448577 A1 20120509; EP 2448577 A4 20121226; EP 2448577 B1 20160914; ES 2600909 T3 20170213; HK 1224206 A1 20170818; IL 217264 A0 20120229; IL 217264 A 20170131; JP 2012531448 A 20121210; JP 2017082019 A 20170518; JP 6159084 B2 20170705; KR 101699572 B1 20170124; KR 20120047240 A 20120511; KR 20170010442 A 20170131; KR 20170116231 A 20171018; MX 2011014006 A 20120612; MX 344787 B 20170105; NZ 597645 A 20140328; PL 2448577 T3 20170228; RU 2012102898 A 20130810; RU 2014136492 A 20160327; RU 2533458 C2 20141120; RU 2671492 C2 20181101; US 2012165357 A1 20120628; US 9486402 B2 20161108

DOCDB simple family (application)

CN 2010000983 W 20100630; AU 2010268647 A 20100630; BR PI1012128 A 20100630; CA 2766834 A 20100630; CN 201080030303 A 20100630; CN 201510859124 A 20100630; EP 10793513 A 20100630; ES 10793513 T 20100630; HK 16112567 A 20161101; IL 21726411 A 20111229; JP 2012518003 A 20100630; JP 2017029388 A 20170220; KR 20127002287 A 20100630; KR 20177001412 A 20100630; KR 20177027790 A 20100630; MX 2011014006 A 20100630; NZ 59764510 A 20100630; PL 10793513 T 20100630; RU 2012102898 A 20100630; RU 2014136492 A 20140908; US 201013379604 A 20100630