EP 2463388 A1 20120613 - Markers for breast cancer

Title (en)

Markers for breast cancer

Title (de)

Marker für Brustkrebs

Title (fr)

Marqueurs du cancer du sein

Publication

EP 2463388 A1 20120613 (EN)

Application

EP 12156417 A 20061129

Priority

EP 06838661 A 20061129
US 74097105 P 20051129
US 78148306 P 20060310

Abstract (en)

Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.

IPC 8 full level

C12Q 1/68 (2006.01)

CPC (source: CN EP KR US)

A61P 35/00 (2017.12 - EP); C12M 1/34 (2013.01 - KR); C12P 19/34 (2013.01 - KR); C12Q 1/6827 (2013.01 - KR); C12Q 1/6886 (2013.01 - CN EP KR US); C12Q 2600/106 (2013.01 - CN EP KR US); C12Q 2600/118 (2013.01 - CN KR); C12Q 2600/136 (2013.01 - EP KR US); C12Q 2600/156 (2013.01 - CN EP KR US); C12Q 2600/16 (2013.01 - EP KR US)

Citation (applicant)

US 4240602 A 20020109
US 23648002 A 20020905
US 34183203 A
US 5925517 A 19990720 - TYAGI SANJAY [US], et al
US 6150097 A 20001121 - TYAGI SANJAY [US], et al
US 6037130 A 20000314 - TYAGI SANJAY [US], et al
US 6174670 B1 20010116 - WITTWER CARL T [US], et al
US 6342355 B1 20020129 - HACIA JOSEPH G [US], et al
US 5468613 A 19951121 - ERLICH HENRY A [US], et al
US 4683202 A 19870728 - MULLIS KARY B [US]
US 6740510 B2 20040525 - KAUTZER CURTIS R [US], et al
US 5045694 A 19910903 - BEAVIS RONALD C [US], et al
US 5202561 A 19930413 - GIESSMANN ULRICH-PETER [US], et al
US 6111251 A 20000829 - HILLENKAMP FRANZ [DE]
US 43818403 A 20030513
US 84531604 A 20040512
US 6242258 B1 20010605 - HASELTON III FREDERICK R [US], et al
US 6500615 B1 20021231 - SCHMIDT GUENTER [GB], et al
US 6498035 B1 20021224 - WYATT JACQUELINE [US]
US 6395544 B1 20020528 - COWSERT LEX M [US], et al
US 5563050 A 19961008 - PEYMAN ANUSCHIRWAN [DE], et al
WO 0168836 A2 20010920 - GENETICA INC [US], et al
WO 0170949 A1 20010927 - BENITEC AUSTRALIA LTD [AU], et al
WO 0175164 A2 20011011 - WHITEHEAD BIOMEDICAL INST [US], et al
US 4376110 A 19830308 - DAVID GARY S, et al
US 4946778 A 19900807 - LADNER ROBERT C [US], et al
US 5932448 A 19990803 - TSO J YUN [US], et al
US 5693762 A 19971202 - QUEEN CARY L [US], et al
US 5693761 A 19971202 - QUEEN CARY L [US], et al
US 5585089 A 19961217 - QUEEN CARY L [US], et al
US 5530101 A 19960625 - QUEEN CARY L [US], et al
US 5569825 A 19961029 - LONBERG NILS [US], et al
US 5625126 A 19970429 - LONBERG NILS [US], et al
US 5633425 A 19970527 - LONBERG NILS [US], et al
US 5789650 A 19980804 - LONBERG NILS [US], et al
US 5661016 A 19970826 - LONBERG NILS [US], et al
US 5770429 A 19980623 - LONBERG NILS [US], et al
US 2003099964 A1 20030529 - PATIL NILA [US], et al
US 95622404 A 20040930
US 6525185 B1 20030225 - FAN JIAN BING [US], et al
SAMBROOK ET AL.: "Molecular Cloning - A Laboratory Manual(3rd Ed.)", vol. 1-3, 2000, COLD SPRING HARBOR LABORATORY
F.M. AUSUBEL ET AL.,: "Current Protocols in Molecular Biology", 2002, GREENE PUBLISHING ASSOCIATES, INC. AND JOHN WILEY & SONS, INC.
INNIS ET AL.: "PCR Protocols A Guide to Methods and Applications", 1990, ACADEMIC PRESS
TIJSSEN: "Laboratory Techniques in Biochemistry and Molecular Biology--Hybridization with Nucleic Acid Probes", 1993, ELSEVIER
HAUGLAND: "Handbook of Fluorescent Probes and Research Chemicals Ninth Edition Ninth Edition", 2003, MOLECULAR PROBES, INC.
LEONE ET AL.: "Molecular beacon probes combined with amplification by NASBA enable homogenous real-time detection of RNA.", NUCLEIC ACIDS RES., vol. 26, 1995, pages 2150 - 2155
TYAGI; KRAMER: "Molecular beacons: probes that fluoresce upon hybridization", NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 303 - 308
BLOK; KRAMER: "Amplifiable hybridization probes containing a molecular switch", MOL CELL PROBES, vol. 11, 1997, pages 187 - 194
HSUIH ET AL.: "Novel, ligation- dependent PCR assay for detection of hepatitis C in serum", J CLIN MICROBIOL, vol. 34, 1997, pages 501 - 507
KOSTRIKIS ET AL.: "Molecular beacons: spectral genotyping of human alleles", SCIENCE, vol. 279, 1998, pages 1228 - 1229
SOKOL ET AL.: "Real time detection of DNA:RNA hybridization in living cells", PROC. NATL. ACAD. SCI. U.S.A., vol. 95, 1998, pages 11538 - 11543
TYAGI ET AL.: "Multicolor molecular beacons for allele discrimination", NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 49 - 53
BONNET ET AL.: "Thermodynamic basis of the chemical specificity of structured DNA probes", PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 6171 - 6176
FANG ET AL.: "Designing a novel molecular beacon for surface-immobilized DNA hybridization studies", J. AM. CHEM. SOC., vol. 121, 1999, pages 2921 - 2922
MARRAS ET AL.: "Multiplex detection of single-nucleotide variation using molecular beacons", GENET. ANAL. BIOMOL. ENG., vol. 14, 1999, pages 151 - 156
VET ET AL.: "Multiplex detection of four pathogenic retroviruses using molecular beacons", PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 6394 - 6399
SAPOLSKY ET AL.: "High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays", GENETIC ANALYSIS: BIOMOLECULAR ENGINEERING, vol. 14, 1999, pages 187 - 192
LOCKHART: "Mutant yeast on drugs", NATURE MEDICINE, vol. 4, 1998, pages 1235 - 1236
FODOR: "Genes, Chips and the Human Genome.", FASEB JOURNAL, vol. 11, 1997, pages A879
FODOR: "Massively Parallel Genomics.", SCIENCE, vol. 277, 1997, pages 393 - 395
CHEE ET AL.: "Accessing Genetic Information with High-Density DNA Arrays.", SCIENCE, vol. 274, 1996, pages 610 - 614
GUATELLI ET AL., PROC NATL ACAD SCI USA, vol. 87, 1990, pages 1874
VOS ET AL., NUCL ACIDS RES, vol. 23, 1995, pages 4407
BECKER ET AL., MOL GEN GENET, vol. 249, 1995, pages 65
MEKSEM ET AL., MOL GEN GENET, vol. 249, 1995, pages 74
ARNHEIM; LEVINSON, C&EN, 1 October 1990 (1990-10-01), pages 36 - 47
THE JOURNAL OF NIH RESEARCH, vol. 3, 1991, pages 81 - 94
KWOH ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 1173
GUATELLI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 1874
LOMELL ET AL., J. CLIN. CHEM, vol. 35, 1989, pages 1826
LANDEGREN ET AL., SCIENCE, vol. 241, 1988, pages 1077 - 1080
VAN BRUNT, BIOTECHNOLOGY, vol. 8, 1990, pages 291 - 294
WU; WALLACE, GENE, vol. 4, 1989, pages 560
BARRINGER ET AL., GENE, vol. 89, 1990, pages 117
SOOKNANAN; MALEK, BIOTECHNOLOGY, vol. 13, 1995, pages 563 - 564
CHENG ET AL., NATURE, vol. 369, 1994, pages 684
ALBERTS ET AL.: "Molecular Biology of the Cell,, 4th Edition", 2002, TAYLOR AND FRANCIS, INC.
LODISH ET AL.: "Molecular Cell Biology, 4th Edition", 1999, W H FREEMAN & CO
R. SCOPES, PROTEIN PURIFICATION, 1982
DEUTSCHER, METHODS IN ENZYMOLOGY, vol. 182
"Guide to Protein Purification", 1990, ACADEMIC PRESS, INC
SANDANA: "Bioseparation of Proteins", 1997, ACADEMIC PRESS
BOLLAG ET AL.: "Protein Methods, 2nd Edition", 1996, WILEY-LISS
WALKER: "The Protein Protocols Handbook", 1996, HUMANA PRESS
HARRIS; ANGAL: "Protein Purification Applications: A Practical Approach", 1990, IRL PRESS
HARRIS; ANGAL: "Protein Purification Methods: A Practical Approach", IRL PRESS
SCOPES: "Protein Purification: Principles and Practice", 1993, SPRINGER VERLAG
JANSON; RYDEN: "Protein Purification: Principles, High Resolution Methods and Applications, Second Edition", 1998, WILEY-VCH
WALKER: "Protein Protocols on CD-ROM", 1998, HUMANA PRESS
AHUJA: "Handbook of Bioseparations", 2000, ACADEMIC PRESS
ISSAQ ET AL.: "SELDI-TOF MS for Diagnostic Proteomics", ANALYTICAL CHEMISTRY, vol. 75, 2003, pages 149A - 155A
BERGER; KIMMEL: "Guide to Molecular Cloning Techniques, Methods in Enzymology", vol. 152, ACADEMIC PRESS, INC.
SAMBROOK ET AL.: "Molecular Cloning - A Laboratory Manual(3rd Ed.),", vol. 1-3, 2001, COLD SPRING HARBOR LABORATORY
F.M. AUSUBEL ET AL.: "Current Protocols in Molecular Biology", GREENE PUBLISHING ASSOCIATES, INC. AND JOHN WILEY & SONS, INC.
BEAUCAGE; CARUTHERS, TETRAHEDRON LETTS., vol. 22, no. 20, 1981, pages 1859 - 1862
NEEDHAM-VANDEVANTER ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 6159 - 6168
F.M. AUSUBEL ET AL.,: "Current Protocols in Molecular Biology", 2004, GREENE PUBLISHING ASSOCIATES, INC. AND JOHN WILEY & SONS, INC.
ATLAS; PARKS: "The Handbook of Microbiological Media", 1993, CRC PRESS
"Science Research Cell Culture Catalogue", 2004, SIGMA- ALDRICH, INC
HARTL: "A Primer of Population Genetics", 1981, SAINT LOUIS SINAUER ASSOCIATES, INC.
LYNCH; WALSH: "Genetics and Analysis of Quantitative Traits", 1998, SINAUER ASSOCIATES, INC.
KEVIN GURNEY: "An Introduction to Neural Networks", 1999, UCL PRESS
BISHOP: "Neural Networks for Pattern Recognition", 1995, OXFORD UNIVERSITY PRESS
RIPLEY ET AL.: "Pattern Recognition and Neural Networks", 1995, CAMBRIDGE UNIVERSITY PRESS
HINCHLIFFE: "Modeling Molecular Structures", 1996, JOHN WILEY AND SONS
GIBAS; JAMBECK: "Bioinformatics Computer Skills", 2001
PEVZNER: "Computational Molecular Biology and Algorithmic Approach", 2000, THE MIT PRESS
DURBIN ET AL.: "Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids", 1998, CAMBRIDGE UNIVERSITY PRESS
RASHIDI; BUEHLER: "Bioinformatic Basics: Applications in Biological Science and Medicine", 2000, CRC PRESS LLC
METHODS FOR GENOMIC ANALYSIS, 26 March 2002 (2002-03-26)
GENETIC ANALYSIS SYSTEMS AND METHODS, 7 January 2002 (2002-01-07)
GENOMIC ANALYSIS, 31 October 2002 (2002-10-31)
APPARATUS AND METHODS FOR ANALYZING AND CHARACTERIZING NUCLEIC ACID SEQUENCES, 30 January 2004 (2004-01-30)
LIVER RELATED DISEASE COMPOSITIONS AND METHODS, 28 May 2003 (2003-05-28)
IMPROVED ANALYSIS METHODS AND APPARATUS FOR INDIVIDUAL GENOTYPING, 20 October 2004 (2004-10-20)
METHODS FOR GENETIC ANALYSIS., 30 September 2004 (2004-09-30)
SERVICE: "Microchips Arrays Put DNA on the Spot", SCIENCE, vol. 282, 1998, pages 396 - 399
ZHANG ET AL.: "Automated and Integrated System for High-Throughput DNA Genotyping Directly from Blood", ANAL. CHEM., vol. 71, 1999, pages 1138 - 1145
SERVICE: "Coming Soon: the Pocket DNA Sequencer", SCIENCE, vol. 282, 1998, pages 399 - 401
R. SCOPES: "Protein Purification", 1982, SPRINGER-VERLAG
DEUTSCHER: "Methods in Enzymology", vol. 182, 1990, ACADEMIC PRESS, INC.
SANDANA: "Bioseparation of Proteins", 1997, ACADEMIC PRESS, INC.
SATINDER AHUJA: "Handbook of Bioseparations", 2000, ACADEMIC PRESS
E. SCHUCH ET AL., SYMP SOC. EXP BIOL, vol. 45, 1991, pages 117 - 127
LANGE ET AL., CURR TOP MICROBIOL IMMUNOL, vol. 197, 1995, pages 57 - 75
HAMILTON ET AL., CURR TOP MICROBIOL IMMUNOL, vol. 197, 1995, pages 77 - 89
FINNEGAN ET AL., PROC NATL ACAD SCI USA, vol. 93, 1996, pages 8449 - 8454
UHLMANN; A. PEPAN, CHEM. REV., vol. 90, 1990, pages 543
P. D. COOK, ANTI-CANCER DRUG DESIGN, vol. 6, 1991, pages 585
J. GOODCHILD, BIOCONJUGATE CHEM. 1, 1990, pages 165
S. L. BEAUCAGE; R. P. IYER, TETRAHEDRON, vol. 49, 1993, pages 6123
F. ECKSTEIN, OLIGONUCLEOTIDES AND ANALOGUES--A PRACTICAL APPROACH, 1991
MCMANUS; SHARP: "Gene silencing in mammals by small interfering RNAs", NATURE REVIEWS GENETICS, vol. 3, 2002, pages 737 - 747
HUTVAGNER; ZAMORE, RNAI: NATURE ABHORS A DOUBLE STRAND, 2002
DEV, CURR OPIN GENET, vol. 200, pages 225 - 232
HANNON: "RNA interference", NATURE, vol. 418, 2002, pages 244 - 251
AGAMI: "RNAi and related mechanisms and their potential use for therapy", CURR OPIN CHEM BIOL, vol. 6, 2002, pages 829 - 834
TUSCHL; BORKHARDT: "Small interfering RNAs: A revolutionary tool for the analysis of gene function and gene therapy", MOLECULAR INTERVENTIONS, vol. 2, 2002, pages 158 - 167
NISHIKURA: "A short primer on RNAi: RNA- directed RNA polymerase acts as a key catalyst", CELL, vol. 107, 2001, pages 415 - 418
ZAMORE: "RNA interference: Listening to the sound of silence", NATURE STRUCTURAL BIOLOGY, vol. 8, 2001, pages 746 - 750
BEACH ET AL., METHODS AND COMPOSITIONS FOR RNA INTERFERENCE
GRAHAM ET AL., GENETIC SILENCING
TUSCHL ET AL., RNA SEQUENCE-SPECIFIC MEDIATORS OF RNA INTERFERENCE
CZAUDEMA ET AL.: "Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells", NUCL ACIDS RES, vol. 31, 2003, pages 2705 - 2716
CAPLEN ET AL.: "Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems", PROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 9742 - 9747
ELBASHIR ET AL.: "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells", NATURE, vol. 411, 2001, pages 494 - 498
ELBASHIR ET AL.: "Analysis of gene function in somatic mammalian cells using small interfering RNAs", METHODS, vol. 26, 2002, pages 199 - 213
KIM ET AL.: "Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy", NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 222 - 226
CZAUDERNA ET AL.: "Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells", NUCL ACIDS RES, vol. 31, 2003, pages 2705 - 2716
MARTINEZ ET AL.: "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi", CELL, vol. 110, 2002, pages 563 - 574
AMARZGUIOUI ET AL.: "Tolerance for mutations and chemical modifications in a siRNA", NUCL. ACIDS RES., vol. 31, 2003, pages 589 - 595
HOLEN ET AL.: "Similar behavior of single-strand and double-strand siRNAs suggests that they act through a common RNAi pathway", NUCL. ACIDS RES., vol. 31, 2003, pages 2401 - 2407
SCHWARZ ET AL., MOL. CELL, vol. 10, 2002, pages 537 - 548
SIOLAS ET AL.: "Synthetic shRNAs as potent RNAi triggers", NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 227 - 231
SCHRAMKE; ALLSHIRE: "Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing", SCIENCE, vol. 301, 2003, pages 1069 - 1074
KAWASAKI; TAIRA: "Induction of DNA methylation and gene silencing by short interfering RNAs in human cells", NATURE, vol. 431, 2004, pages 211 - 217
MORRIS ET AL.: "Small interfering RNA-induced transcriptional gene silencing in human cells", SCIENCE, vol. 305, 2004, pages 1289 - 1292
ZENG ET AL.: "MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms", PROC. NATL. ACAD. SCI. USA, vol. 100, 2003, pages 9779 - 9784
DOENCH ET AL.: "siRNAs can function as miRNAs", ENES & DEV., vol. 17, 2003, pages 438 - 442
BARTEL; BARTEL: "MicroRNAs: At the root of plant development?", PLANT PHYSIOLOGY, vol. 132, 2003, pages 709 - 717
SCHWARZ; ZAMORE: "Why do miRNAs live in the miRNP?", GENES & DEV., vol. 16, 2002, pages 1025 - 1031
TANG ET AL.: "A biochemical framework for RNA silencing in plants", GENES & DEV., vol. 17, 2003, pages 49 - 63
MEISTER ET AL.: "Sequence-specific inhibition of microRNA- and siRNA- induced RNA silencing", RNA, vol. 10, 2004, pages 544 - 550
NELSON ET AL.: "The microRNA world: Small is mighty", TRENDS BIOCHEM. SCI., vol. 28, 2003, pages 534 - 540
SCACHERI ET AL.: "Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells", PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 1892 - 1897
SEMPERE ET AL.: "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation", GENOME BIOLOGY, vol. 5, 2004, pages R13
DYKXHOOM ET AL.: "Killing the messenger: Short RNAs that silence gene expression", NATURE REVIEWS MOLEC. AND CELL BIOL., vol. 4, 2003, pages 457 - 467
MCMANUS: "MicroRNAs and cancer", SEMIN CANCER BIOL., vol. 13, 2003, pages 253 - 288
STARK ET AL.: "Identification of Drosophila microRNA targets", PLOS BIOL., vol. 1, 2003, pages E60
DOENCH; SHARP: "Specificity of microRNA target selection in translational repression", GENES & DEV., vol. 18, 2004, pages 504 - 511
REHMSMEIER ET AL.: "Fast and effective prediction of microRNA/target duplexes", RNA, vol. 10, 2004, pages 1507 - 1517
ROBINS ET AL.: "Incorporating structure to predict microRNA targets", PROC NATL ACAD SCI, vol. 102, 2005, pages 4006 - 4009
MATTICK; MAKUNIN: "Small regulatory RNAs in mammals", HUM. MOL. GENET., vol. 14, 2005, pages R121 - R132
MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
KOSBOR ET AL., IMMUNOLOGY TODAY, vol. 4, 1983, pages 72
COLE ET AL., PROC. NAT'L. ACAD. SCI. USA, vol. 80, 1983, pages 2026 - 2030
COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, INC., pages: 77 - 96
MORRISON ET AL., PROC. NAT'L. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
NEUBERGER ET AL., NATURE, vol. 312, 1984, pages 604 - 608
TAKEDA ET AL., NATURE, vol. 314, 1985, pages 452 - 454
BIRD, SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NAT'L. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
WARD ET AL., NATURE, vol. 334, 1989, pages 544 - 546
HUSE ET AL., SCIENCE, vol. 246, 1989, pages 1275 - 1281
LANCET, LANCET, vol. 358, pages 1389 - 1399
LICHTENSTEIN P ET AL., NEW ENGL J MED, vol. 243, 2000, pages 78 - 85
PETO J; MACK TM, NATURE GENET, vol. 26, 2000, pages 411 - 414
ANTONIOU A ET AL., AM J HUM GENET, vol. 72, 2003, pages 1117 - 1130
PETO J ET AL., J NATL CANCER INST, vol. 91, 1989, pages 943 - 949
BR J CANCER, vol. 83, 2000, pages 1301 - 1308
EASTON DF, CANCER RES, vol. 1, 1999, pages 1 - 4
FORD D ET AL., AM J HUM GENET, vol. 62, 1998, pages 334 - 345
THOMPSON D ET AL., PROC NATL ACAD SCI USA, vol. 99, 2002, pages 827 - 831
HUUSKO P ET AL., EUR J HUM GENET, 2003
ANTONIOU AC ET AL., GENET EPIDEMIOL, vol. 21, 2001, pages 1 - 18
CUI J ET AL., AM J HUM GENET, vol. 68, 2000, pages 420 - 431
ANTONIOU AC ET AL., BRIT J CANCER, vol. 86, 2002, pages 76 - 83
PHAROAH PDP ET AL., NATURE GENETICS, vol. 31, 2002, pages 33 - 36
TITUS-EMSTOFF L ET AL., CANCER EPIDEMIOL BIOMARKERS PREV, vol. 7, 1998, pages 783 - 9
KRIEGE ET AL., PROC AM SOC CLIN ONCOL, vol. 22, 2003, pages A5
PATIL N ET AL., SCIENCE, vol. 294, 2001, pages 1719 - 1723
ZHANG K ET AL., PROC NATL ACAD SCI USA, vol. 99, 2002, pages 7335 - 7339
PRITCHARD JK; PRZEWORSKI M, AM J HUM GENET, vol. 69, 2001, pages 1 - 14
DUNNING AM ET AL., CANCER EPIDEMIOL BIOMARKERS PREVENTION, vol. 8, 1999, pages 843 - 854
HEALEY CS ET AL., NATURE GENET, vol. 26, 2000, pages 362 - 364
KUSCHEL B ET AL., HUM MOL GENET, vol. 11, 2002, pages 1399 - 1407
DUNNING AM ET AL., CANCER RES, vol. 63, 2003, pages 2610 - 15
DAY N ET AL., BR J CANCER 80, vol. 1, 1999, pages 95 - 103
GOODE EL ET AL., GENET EPIDEMIOL, vol. 21, 2001, pages A126
ANTONIOU A; EASTON DF, GENET EPIDEMIOL, vol. 25, 2003, pages 190 - 202
SATAGOPAN JM ET AL., BIOMETRICS, vol. 58, 2002, pages 163 - 170
DUNNING AM ET AL., J NATL CANCER INST, 2004
SASIENI PD, BIOMETRICS, vol. 53, 1997, pages 1253 - 1261
CHAPMAN JP ET AL., HUM HERED, vol. 56, 2003, pages 18 - 31

Citation (search report)

[I] WO 2004048546 A2 20040610 - SEQUENOM INC [US]
[I] US 2003232398 A1 20031218 - MACMURRAY JAMES P [US], et al
[I] J. LISTGARTEN: "Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms", CLINICAL CANCER RESEARCH, vol. 10, no. 8, 15 April 2004 (2004-04-15), pages 2725 - 2737, XP055018552, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-1115-03
[X] DATABASE dbSNP [online] NCBI; 1 June 2004 (2004-06-01), "Reference SNP(refSNP) Cluster Report: rs13281615", XP002674327, Database accession no. rs13281615
[T] EASTON D F ET AL: "Genome-wide association study identifies novel breast cancer susceptibility loci", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 447, 28 June 2007 (2007-06-28), pages 1087 - 1095, XP002547799, ISSN: 0028-0836, [retrieved on 20070527], DOI: 10.1038/NATURE05887
[T] A. C. ANTONIOU ET AL: "Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers", HUMAN MOLECULAR GENETICS, vol. 18, no. 22, 5 August 2009 (2009-08-05), pages 4442 - 4456, XP055025106, ISSN: 0964-6906, DOI: 10.1093/hmg/ddp372

Designated contracting state (EPC)

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