EP 2464667 A2 20120620 - N-ACYLATED OCTASACCHARIDES ACTIVATING FGFS RECEPTORS, THEIR SYNTHESIS AND THEIR THERAPEUTICAL APPLICATION
Title (en)
N-ACYLATED OCTASACCHARIDES ACTIVATING FGFS RECEPTORS, THEIR SYNTHESIS AND THEIR THERAPEUTICAL APPLICATION
Title (de)
FGFS-REZEPTOREN AKTIVIERENDE N-ACYLIERTE OCTASACCHARIDE, IHRE SYNTHESE UND IHRE THERAPEUTISCHE ANWENDUNG
Title (fr)
OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
Publication
Application
Priority
- FR 0903968 A 20090814
- FR 2010051703 W 20100812
Abstract (en)
[origin: WO2011018588A2] The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an OSO3- or hydroxyl group, R3 is an alkyl, cycloalkyl, or alky-cycloalkyl group, R4 is a disaccharide having Formula (II), R6 is a disaccharide having Formula (III), and R8 is a disaccharide having Formula (IV), where R5, R7, and R9 have OSO3 or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
IPC 8 full level
A61K 31/737 (2006.01); A61P 7/00 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 17/00 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 37/00 (2006.01); C08B 37/00 (2006.01)
CPC (source: EP US)
A61K 31/737 (2013.01 - EP US); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/14 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 27/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07H 11/00 (2013.01 - EP US); C07H 15/04 (2013.01 - EP US); C07H 15/203 (2013.01 - EP US); C08B 37/0063 (2013.01 - EP US); C08B 37/0075 (2013.01 - EP US)
Citation (search report)
See references of WO 2011018588A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
BA ME RS
DOCDB simple family (publication)
WO 2011018588 A2 20110217; WO 2011018588 A3 20110707; AR 078094 A1 20111012; AU 2010283614 A1 20120308; AU 2010283614 B2 20160331; BR 112012007883 A2 20160315; CA 2771056 A1 20110217; CA 2771056 C 20171114; CL 2012000393 A1 20120907; CN 102574931 A 20120711; CN 102574931 B 20140702; CO 6612193 A2 20130201; DO P2012000037 A 20120415; EA 020485 B1 20141128; EA 201270277 A1 20120928; EC SP12011671 A 20120330; EP 2464667 A2 20120620; FR 2949114 A1 20110218; FR 2949114 B1 20110826; IL 218068 A0 20120430; IL 218068 A 20150730; JP 2013501839 A 20130117; JP 5671536 B2 20150218; KR 101718567 B1 20170321; KR 20120106716 A 20120926; MA 33573 B1 20120901; MX 2012001947 A 20120912; NI 201200026 A 20120524; NZ 598174 A 20140131; PE 20120915 A1 20120817; SG 10201404221R A 20140926; SG 178405 A1 20120329; TN 2012000052 A1 20130919; TW 201109020 A 20110316; TW I572615 B 20170301; US 2012214754 A1 20120823; US 9012413 B2 20150421; UY 32843 A 20110331; ZA 201201028 B 20130731
DOCDB simple family (application)
FR 2010051703 W 20100812; AR P100102985 A 20100813; AU 2010283614 A 20100812; BR 112012007883 A 20100812; CA 2771056 A 20100812; CL 2012000393 A 20120214; CN 201080046585 A 20100812; CO 12024409 A 20120213; DO 2012000037 A 20120208; EA 201270277 A 20100812; EC SP12011671 A 20120213; EP 10761049 A 20100812; FR 0903968 A 20090814; IL 21806812 A 20120212; JP 2012524265 A 20100812; KR 20127006510 A 20100812; MA 34673 A 20120308; MX 2012001947 A 20100812; NI 201200026 A 20120213; NZ 59817410 A 20100812; PE 2012000205 A 20100812; SG 10201404221R A 20100812; SG 2012010203 A 20100812; TN 2012000052 A 20120203; TW 99127180 A 20100813; US 201213369675 A 20120209; UY 32843 A 20100813; ZA 201201028 A 20120213