EP 2464741 A1 20120620 - METHODS OF DETECTING RESPONSES TO THERAPIES USING PERFORIN LEVELS
Title (en)
METHODS OF DETECTING RESPONSES TO THERAPIES USING PERFORIN LEVELS
Title (de)
VERFAHREN ZUR ERKENNUNG DES ANSPRECHENS AUF THERAPIEN UNTER VERWENDUNG VON PERFORINSPIEGELN
Title (fr)
PROCÉDÉS DE DÉTECTION DE RÉPONSES À DES THÉRAPIES UTILISANT LES NIVEAUX DE PERFORINE
Publication
Application
Priority
- US 23260509 P 20090810
- US 2010044921 W 20100809
Abstract (en)
[origin: WO2011019670A1] Methods and kits for detecting positive responses to therapies, diagnosing a disease or condition, and detecting impending clinical relapse. The method may feature obtaining a sample from a patient and either detecting a percentage of perforin+ natural killer (NK) cells or detecting a level of perforin expression in the sample. Positive responses to the therapy may be detected if the percentage of perforins NK ceils is greater than or equal to about 75% of total NK ceils or if the level of perforin expression in the sample is within a ievel of perforin expression in a normal sample +/-25%. The disease or condition or impending clinical relapse may be detected if the ievel of perforin expression in the sample is less than a level of perforin expression in a normal sample minus about 25% or the percentage of perforin+ NK ceils is less than about 75% of total NK cells.
IPC 8 full level
G01N 33/68 (2006.01)
CPC (source: EP)
G01N 33/6896 (2013.01); G01N 2333/70535 (2013.01); G01N 2800/285 (2013.01); G01N 2800/52 (2013.01); G01N 2800/54 (2013.01); G01N 2800/56 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
BA ME RS
DOCDB simple family (publication)
WO 2011019670 A1 20110217; CA 2770680 A1 20110217; EP 2464741 A1 20120620; EP 2464741 A4 20130522
DOCDB simple family (application)
US 2010044921 W 20100809; CA 2770680 A 20100809; EP 10808602 A 20100809