EP 2464749 A1 20120620 - CDC45L AS TUMOR MARKER AND THERAPEUTIC TARGET FOR CANCER
Title (en)
CDC45L AS TUMOR MARKER AND THERAPEUTIC TARGET FOR CANCER
Title (de)
CDC45L ALS TUMORMARKER UND THERAPIEMITTEL GEGEN KREBS
Title (fr)
CDC45L COMME MARQUEUR TUMORAL ET CIBLE THÉRAPEUTIQUE POUR LE CANCER
Publication
Application
Priority
- US 27424809 P 20090813
- JP 2010005049 W 20100812
Abstract (en)
[origin: WO2011018898A1] The present invention is based on the finding that CDC45L gene and PIF1 gene are everexpressed in cancer, and involved in cancer cell survival. The present invention features methods for diagnosing cancer or assessing/determining the prognosis of a subject with cancer, using CDC45L gene and/or PIF1 gene as diagnostic markers. The present invention also features a double-stranded molecule against CDC45L gene or PIF1 gene, a method or composition for treating and/or preventing cancer using such double-stranded molecule Also, disclosed are methods of identifying a candidate compound for treating and preventing lung cancer, using CDC45L and/or PIF1 as molecular targets.
IPC 8 full level
C12Q 1/68 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61P 11/00 (2017.12); A61P 35/00 (2017.12); C12N 15/1135 (2013.01); C12N 15/1137 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57423 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4706 (2013.01); G01N 2500/02 (2013.01)
Citation (search report)
See references of WO 2011018898A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2011018898 A1 20110217; CN 102575297 A 20120711; EP 2464749 A1 20120620; JP 2013501501 A 20130117
DOCDB simple family (application)
JP 2010005049 W 20100812; CN 201080046172 A 20100812; EP 10808083 A 20100812; JP 2012507486 A 20100812