Global Patent Index - EP 2467481 A4

EP 2467481 A4 20130116 - TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A SIRTUIN (SIRT)

Title (en)

TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A SIRTUIN (SIRT)

Title (de)

BEHANDLUNG VON SIRTUIN (SIRT)-BEDINGTEN ERKRANKUNGEN MITTELS HEMMUNG DES NATÜRLICHEN ANTISENSE-TRANSKRIPTS GEGEN EIN SIRTUIN (SIRT)

Title (fr)

TRAITEMENT DES MALADIES ASSOCIÉES À UNE SIRTUINE (SIRT) PAR INHIBITION DU PRODUIT DE TRANSCRIPTION ANTI-SENS NATUREL CHEZ UNE SIRTUINE (SIRT)

Publication

EP 2467481 A4 20130116 (EN)

Application

EP 10802960 A 20100723

Priority

  • US 22839209 P 20090724
  • US 25907209 P 20091106
  • US 2009066445 W 20091202
  • US 2010026119 W 20100303
  • US 33042710 P 20100503
  • US 2010043075 W 20100723

Abstract (en)

[origin: EP2985348A2] The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.

IPC 8 full level

C12N 15/63 (2006.01); C07H 19/00 (2006.01); C12N 15/11 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

C12N 15/1137 (2013.01); C12Y 305/01098 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01)

Citation (search report)

  • [XI] JP 2008195673 A 20080828 - NIPPON MEAT PACKERS, et al & DATABASE Geneseq [online] 30 October 2008 (2008-10-30), "Human SIRT1 gene HA044263-R RT-PCR primer, SEQ ID NO:11.", retrieved from EBI accession no. GSN:ATF64187 Database accession no. ATF64187 & DATABASE Geneseq [online] 30 October 2008 (2008-10-30), "Human SIRT1 gene HA044263-F RT-PCR primer, SEQ ID NO:10.", retrieved from EBI accession no. GSN:ATF64186 Database accession no. ATF64186
  • [XI] WO 2006069592 A2 20060706 - VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG [NL], et al
  • [XP] WO 2009140562 A1 20091119 - SIRTRIS PHARMACEUTICALS INC [US], et al
  • [X] WO 2006006171 A2 20060119 - GAMIDA CELL LTD [IL], et al
  • [A] US 2008108583 A1 20080508 - FEINSTEIN ELENA [IL]
  • [A] WO 9727332 A1 19970731 - INNOGENETICS NV [BE], et al
  • [A] US 2005136395 A1 20050623 - MITTMANN MICHAEL P [US], et al & DATABASE Geneseq [online] 4 October 2007 (2007-10-04), "SARS coronavirus related nucleic acid probe SEQ ID NO 83591.", retrieved from EBI accession no. GSN:AFA01179 Database accession no. AFA01179
  • [XI] EP 1757306 A1 20070228 - GENECARE RES INST CO LTD [JP]
  • [XP] WO 2010065662 A2 20100610 - CURNA INC [US], et al
  • [XI] SUN ET AL: "Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells", LUNG CANCER, ELSEVIER, AMSTERDAM, NL, vol. 58, no. 1, 14 September 2007 (2007-09-14), pages 21 - 29, XP022242948, ISSN: 0169-5002, DOI: 10.1016/J.LUNGCAN.2007.05.013
  • [A] WAHLESTEDT ET AL: "Natural antisense and noncoding RNA transcripts as potential drug targets", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 11, no. 11-12, 1 June 2006 (2006-06-01), pages 503 - 508, XP027889295, ISSN: 1359-6446, [retrieved on 20060601]
  • [XI] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 2008 (2008-10-01), KUEHBACHER ANGELIKA ET AL: "MicroRNA 92a Controls Vessel Growth And Functional Recovery After Ischemia", XP002684082, Database accession no. PREV200900197869
  • [XI] MUNEKAZU YAMAKUCHI ET AL: "miR-34a repression of SIRT1 regulates apoptosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13421 - 13426, XP008149911, ISSN: 0027-8424, [retrieved on 20080828], DOI: 10.1073/PNAS.0801613105
  • [A] SMALHEISER N R ET AL: "Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain", NEUROSCIENCE RESEARCH, ELSEVIER, SHANNON, IR, vol. 62, no. 4, 1 December 2008 (2008-12-01), pages 236 - 239, XP025669354, ISSN: 0168-0102, [retrieved on 20080904], DOI: 10.1016/J.NEURES.2008.08.010
  • [A] THIMMAPPA S. ANEKONDA ET AL: "Neuronal protection by sirtuins in Alzheimer's disease", JOURNAL OF NEUROCHEMISTRY, vol. 96, no. 2, 1 January 2006 (2006-01-01), pages 305 - 313, XP055039113, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2005.03492.x
  • [A] APARNA PURUSHOTHAM ET AL: "Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation", CELL METABOLISM, vol. 9, no. 4, 8 April 2009 (2009-04-08), pages 327 - 338, XP055039151, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2009.02.006
  • [X] BONAUER ANGELIKA ET AL: "MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 324, no. 5935, 21 May 2009 (2009-05-21), pages 1710 - 1713, XP002575234, ISSN: 0036-8075 & A. BONAUER ET AL: "Supporting Online Material for MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice", SCIENCE, 21 May 2009 (2009-05-21), pages 1 - 35, XP055042749, Retrieved from the Internet <URL:http://www.sciencemag.org/content/suppl/2009/05/21/1174381.DC1/Bonauer_SOM.pdf> [retrieved on 20121031]
  • See references of WO 2011011700A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

EP 2985348 A2 20160217; EP 2985348 A3 20160420; EP 2985348 B1 20201230; EP 2467481 A2 20120627; EP 2467481 A4 20130116; ES 2854004 T3 20210920; HK 1219758 A1 20170413

DOCDB simple family (application)

EP 15180289 A 20100723; EP 10802960 A 20100723; ES 15180289 T 20100723; HK 16107821 A 20160705