EP 2471777 A4 20130102 - NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS
Title (en)
NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS
Title (de)
NEUARTIGE TETRAHYDROISOCHINOLINVERBINDUNGEN
Title (fr)
NOUVEAUX COMPOSÉS DE TÉTRAHYDROISOQUINOLINE
Publication
Application
Priority
- JP 2009198540 A 20090828
- JP 2010064550 W 20100827
Abstract (en)
[origin: EP2471777A1] The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, or the like, or a pharmacologically acceptable salt thereof.
IPC 8 full level
A61K 31/472 (2006.01); A61P 1/16 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 15/08 (2006.01); A61P 27/02 (2006.01); A61P 43/00 (2006.01); C07D 217/06 (2006.01)
CPC (source: EP KR US)
A61K 31/472 (2013.01 - KR); A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/08 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/48 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/06 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/12 (2017.12 - EP); A61P 31/14 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 217/06 (2013.01 - EP KR US)
Citation (search report)
- [AD] US 2007249620 A1 20071025 - KURATA HITOSHI [JP], et al
- [E] EP 2256105 A1 20101201 - DAIICHI SANKYO CO LTD [JP]
- See references of WO 2011024932A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2471777 A1 20120704; EP 2471777 A4 20130102; AU 2010287464 A1 20120315; BR 112012004487 A2 20160322; CA 2790390 A1 20110303; CN 102471276 A 20120523; CO 6430504 A2 20120430; IL 218331 A0 20120430; IN 1203DEN2012 A 20150410; JP WO2011024932 A1 20130131; KR 20120067333 A 20120625; MX 2012002466 A 20120314; NZ 598535 A 20130726; RU 2012111837 A 20131010; SG 178299 A1 20120329; TW 201109306 A 20110316; US 2012202847 A1 20120809; WO 2011024932 A1 20110303; ZA 201200956 B 20121031
DOCDB simple family (application)
EP 10811981 A 20100827; AU 2010287464 A 20100827; BR 112012004487 A 20100827; CA 2790390 A 20100827; CN 201080038232 A 20100827; CO 12047670 A 20120321; IL 21833112 A 20120227; IN 1203DEN2012 A 20120209; JP 2010064550 W 20100827; JP 2011528857 A 20100827; KR 20127004935 A 20100827; MX 2012002466 A 20100827; NZ 59853510 A 20100827; RU 2012111837 A 20100827; SG 2012008496 A 20100827; TW 99128825 A 20100827; US 201213404836 A 20120224; ZA 201200956 A 20120208