Title (en)

A METHOD OF CRYSTALLIZATION OF (S)-N-METHYL-3-(1-NAPHTHYLOXY)-3- (2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE)

Title (de)

VERFAHREN ZUR KRISTALLISIERUNG VON (S)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)-PROPYLAMIN-HYDROCHLORID (DULOXETIN)

Title (fr)

PROCÉDÉ DE CRISTALLISATION DE CHLORHYDRATE DE (S)-N-MÉTHYL-3- (1-NAPHTYLOXY)-3-(2-THIÉNYL)PROPYLAMINE (DULOXÉTINE)

Publication

EP 2473497 A1 20120711 (EN)

Application

EP 10771629 A 20100902

Priority

• CZ 2009584 A 20090902
• CZ 2010000099 W 20100902

Abstract (en)

[origin: WO2011026449A1] (S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride of formula (I) is crystallized in such a way that suspension of duloxetine in a mixture of an aprotic solvent and a protic solvent is stirred at an increased temperature under simultaneous reduction of the volume proportion of the protic solvent.

IPC 8 full level

C07D 333/16 (2006.01); C07D 333/20 (2006.01)

CPC (source: EP KR)

A61K 31/381 (2013.01 - KR); A61P 13/10 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 333/16 (2013.01 - EP KR); C07D 333/20 (2013.01 - EP KR)

Citation (search report)

See references of WO 2011026449A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2011026449 A1 20110310; BR 112012004862 A2 20150908; CN 102482254 A 20120530; CZ 2009584 A3 20110309; CZ 304602 B6 20140730; EA 021528 B1 20150730; EA 201290127 A1 20130228; EP 2473497 A1 20120711; IL 218329 A0 20120430; JP 2013503823 A 20130204; KR 20120047262 A 20120511; MX 2012002621 A 20120703; ZA 201201570 B 20130828

DOCDB simple family (application)

CZ 2010000099 W 20100902; BR 112012004862 A 20100902; CN 201080039237 A 20100902; CZ 2009584 A 20090902; EA 201290127 A 20100902; EP 10771629 A 20100902; IL 21832912 A 20120227; JP 2012527196 A 20100902; KR 20127004225 A 20100902; MX 2012002621 A 20100902; ZA 201201570 A 20120301