Global Patent Index - EP 2474613 A1

EP 2474613 A1 20120711 - Methods and compositions

Title (en)

Methods and compositions

Title (de)

Verfahren und Zusammensetzungen

Title (fr)

Procédés et compositions

Publication

EP 2474613 A1 20120711 (EN)

Application

EP 12151953 A 20090204

Priority

  • GB 0802079 A 20080205
  • GB 0818399 A 20081008
  • EP 09708496 A 20090204
  • GB 2009000301 W 20090204

Abstract (en)

The invention relates to a complex comprising a phage particle, said phage particle comprising (i) a polypeptide; (ii) a nucleic acid encoding the polypeptide of (i); (iii) a connector compound attached to said polypeptide wherein said connector compound is attached to the polypeptide by at least three discrete covalent bonds. The invention also relates to libraries, and to methods for making complexes and to methods of screening using same.

IPC 8 full level

C12N 15/10 (2006.01); A61K 47/48 (2006.01); C40B 30/04 (2006.01); C40B 40/02 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP US)

A61K 47/54 (2017.08 - EP US); A61K 47/55 (2017.08 - EP US); A61K 47/64 (2017.08 - EP US); C07K 1/1075 (2013.01 - EP US); C07K 1/1077 (2013.01 - EP US); C07K 14/005 (2013.01 - US); C12N 15/1037 (2013.01 - EP US); C12N 15/1041 (2013.01 - EP US); C12N 15/1062 (2013.01 - EP US); C12N 15/1068 (2013.01 - EP US); C40B 40/08 (2013.01 - EP US); C40B 50/06 (2013.01 - EP US); G01N 33/56983 (2013.01 - EP US); C40B 40/10 (2013.01 - US)

Citation (applicant)

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Citation (search report)

  • [YD] WO 2006078161 A1 20060727 - PEPSCAN SYSTEMS BV [NL], et al
  • [YD] WO 2004077062 A2 20040910 - PEPSCAN SYSTEMS BV [NL], et al
  • [YD] MILLWARD S W ET AL: "A General Route for Post-Translational Cyclization of mRNA Display Libraries", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 41, 19 October 2005 (2005-10-19), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC; US, pages 14142 - 14143, XP008119248, ISSN: 0002-7863, [retrieved on 20050927], DOI: 10.1021/JA054373H
  • [YD] MILLWARD STEVEN W ET AL: "Design of cyclic peptides that bind protein surfaces with antibody-like affinity", ACS CHEMICAL BIOLOGY, vol. 2, no. 9, 1 January 2007 (2007-01-01), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, pages 625 - 634, XP002616292, ISSN: 1554-8929, [retrieved on 20070921], DOI: 10.1021/CB7001126
  • [YD] TIMMERMAN P ET AL: "Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, vol. 6, no. 5, 1 May 2005 (2005-05-01), WILEY VCH, WEINHEIM, DE, pages 821 - 824, XP002378236, ISSN: 1439-4227
  • [XP] LITOVCHICK ALEXANDER ET AL: "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 40, 7 October 2008 (2008-10-07), pages 15293 - 15298+RETR, XP002676077, ISSN: 1091-6490 & ALEXANDER LITOVCHICK AND JACK W. SOSTAK: "Supporting information: Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display", PNAS, 7 October 2008 (2008-10-07), pages 1 - 10, XP002676078
  • [T] LITOVCHICK ALEXANDER ET AL: "Retraction for Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, no. 17, 28 April 2009 (2009-04-28), pages 7263, XP002676079, ISSN: 1091-6490
  • [T] HEINIS CHRISTIAN ET AL: "Phage-encoded combinatorial chemical libraries based on bicyclic peptides", NATURE CHEMICAL BIOLOGY, vol. 5, no. 7, 31 May 2009 (2009-05-31), NATURE PUBLISHING GROUP, NEW YORK, NY, US, pages 502 - 507, XP002588858, ISSN: 1552-4450, DOI: 10.1038/NCHEMBIO.184 & HEINIS CHRISTIAN ET AL: "Phage-encoded combinatorial chemical libraries based on bicyclic peptides, Supplementary Material", NATURE CHEMICAL BIOLOGY,, 31 May 2009 (2009-05-31), pages 1 - 17, XP002676080

Citation (third parties)

Third party :

  • WO 2004077062 A2 20040910 - PEPSCAN SYSTEMS BV [NL], et al
  • S.W. MILLWARD ET ALL.: "A GENERAL ROUTE FOR POST-TRANSLATIONAL CYCLIZATION OF MRNA DISPLAY LIBRARIES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 41, 19 October 2005 (2005-10-19), pages 14142 - 14143, XP008119248, DOI: 10.1021/JA05437H
  • S.W. MILLWARD ET ALL.: "DESIGN OF CYCLIC PEPTIDES THAT BIND PROTEIN SURFACES WITH ANTIBODY-LIKE AFFINITY", ACS CHEMICAL BIOLOGY, vol. 2, no. 9, 1 January 2007 (2007-01-01), USA, pages 625 - 634, XP002616292, DOI: 10.1021/CB7001126
  • P. TIMMERMAN ET AL: "RAPID AND QUANTITATIVE CYCLIZATION OF MULTIPLE PEPTIDE LOOPS ONTO SYNTHETIC SCAFFOLDS FOR STRUCTURAL MIMICRY OF PROTEIN SURFACES", CHEMBIOCHEM- A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, vol. 6, no. 5, 1 May 2005 (2005-05-01), DE, pages 821 - 824, XP002378236, DOI: 10.1002/CBIC.200400374
  • A. LITOVCHICK, J.W. SZOSTAK: "SELECTION OF CYCLIC PEPTIDE APTAMERS TO HCV IRES RNA USING MRNA DISPLAY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 40, 7 October 2008 (2008-10-07), USA, pages 15293 - 15298, XP002676077, DOI: 10.1073/PNAS.0805837105
  • A. LITOVCHICK, J.W. SZOSTAK, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 17, 28 April 2009 (2009-04-28), USA, pages 7263, XP002676079, DOI: 10.1073/PNAS.0903110106
  • DAVID S. WILSON ET AL.: "THE USE OF MRNA DISPLAY TO SELECT HIGH-AFFINITY PROTEIN-BINDING PEPTIDES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 98, no. 7, 27 March 2001 (2001-03-27), USA, pages 3750 - 3755, XP002209215, DOI: 10.1073/PNAS.061028198

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

DOCDB simple family (publication)

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DOCDB simple family (application)

GB 2009000301 W 20090204; AT 09708496 T 20090204; AU 2009211253 A 20090204; CA 2714477 A 20090204; DK 09708496 T 20090204; DK 12151953 T 20090204; EP 09708496 A 20090204; EP 12151953 A 20090204; EP 13167202 A 20090204; EP 13167203 A 20090204; EP 13167204 A 20090204; ES 09708496 T 20090204; ES 12151953 T 20090204; JP 2010545546 A 20090204; JP 2015011208 A 20150123; PL 09708496 T 20090204; PT 09708496 T 20090204; US 201313973297 A 20130822; US 201414339327 A 20140723; US 86621409 A 20090204