EP 2480242 A1 20120801 - LIPOPOLYSACCHARIDE ISOLATED FROM PYRULARIA TISSUE AND/OR PYRULARIA-ASSOCIATED BACTERIA AND USES THEREOF
Title (en)
LIPOPOLYSACCHARIDE ISOLATED FROM PYRULARIA TISSUE AND/OR PYRULARIA-ASSOCIATED BACTERIA AND USES THEREOF
Title (de)
AUS PYRROLURIE-GEWEBE UND/ODER MIT PYRROLURIE-BAKTERIEN ISOLIERTES LIPOPOLYSACCHARID UND VERWENDUNGEN DAVON
Title (fr)
LIPOPOLYSACCHARIDE ISOLÉ DE TISSU DE PYRULARIA ET/OU BACTÉRIE ASSOCIÉE À PYRULARIA ET LEURS UTILISATIONS
Publication
Application
Priority
- US 24563909 P 20090924
- US 2010050133 W 20100924
Abstract (en)
[origin: WO2011038186A1] This disclosure provides, in certain embodiments, methods for generating and using extracts of Pyrularia (e.g., Pyrularia pubera) and/or an epiphytic/endophytic bacteria associated therewith, either alone or in combination with conventional immunostimulant(s) or anti-inflammatory agents, for modulation of the immune system of a subject. Also provided are compositions that include specific Pyrularia extracts, bacteria isolated from Pyrularia tissue (in particular, Pantoea species), and extracts of from such bacteria. Also provided herein are purified components of Pyrularia extracts and/or extracts from the epiphytic/endophytic bacteria, which extracts exhibit mitogenic or cytotoxic activities. Compositions provided herein can be used for the treatment of neutropenia subsequent to chemotherapy, and for the treatment of immune deficiency (e.g., such as is caused by toxic chemotherapy, disease, or advancing age), as well as in other immune- stimulatory methods. Other embodiments of the invention provide methods of producing extracts of the invention, as well as purified bioactive components thereof, including particularly bacterial LPS.
IPC 8 full level
A61K 36/185 (2006.01); A61K 35/74 (2006.01); A61P 37/04 (2006.01)
CPC (source: EP)
A61K 35/74 (2013.01); A61K 36/185 (2013.01); A61P 37/04 (2017.12)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2011038186 A1 20110331; AU 2010298191 A1 20120419; CA 2773351 A1 20110331; EP 2480242 A1 20120801; EP 2480242 A4 20130313
DOCDB simple family (application)
US 2010050133 W 20100924; AU 2010298191 A 20100924; CA 2773351 A 20100924; EP 10819505 A 20100924