EP 2480579 A4 20130731 - METHODS OF TREATING INFLAMMATION
Title (en)
METHODS OF TREATING INFLAMMATION
Title (de)
VERFAHREN ZUR BEHANDLUNG VON ENTZÜNDUNGEN
Title (fr)
MÉTHODES DE TRAITEMENT D'UNE INFLAMMATION
Publication
Application
Priority
- US 31903910 P 20100330
- US 24521409 P 20090923
- US 2010050047 W 20100923
Abstract (en)
[origin: WO2011038149A2] Disclosed herein, in some embodiments, are methods for treating an MIF-mediated disorder. In some embodiments, the method comprises administering an agent that inhibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF- activation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof.
IPC 8 full level
C07K 19/00 (2006.01); A61K 38/18 (2006.01); A61P 35/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/435 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2017.12 - EP); C07K 7/06 (2013.01 - EP KR); C07K 7/08 (2013.01 - EP KR); C07K 14/435 (2013.01 - KR); C07K 14/52 (2013.01 - EP); C07K 19/00 (2013.01 - KR); A61K 38/00 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); Y02A 50/30 (2017.12 - EP)
Citation (search report)
- [XP] US 2010183598 A1 20100722 - SCHULTZ JOSHUA ROBERT [US], et al
- [XY] JÜRGEN BERNHAGEN ET AL: "MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 13, no. 5, 5 March 2007 (2007-03-05), pages 587 - 596, XP008140753, ISSN: 1078-8956, DOI: 10.1038/NM1567
- [Y] WEBER CHRISTIAN ET AL: "Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 42, October 2008 (2008-10-01), pages 16278 - 16283, XP002699220, ISSN: 0027-8424
- [Y] WEBER ET AL: "Abstract: 559 CHEMOKINES AS THERAPEUTIC TARGETS IN ATHEROSCLEROSIS", ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER, AMSTERDAM, NL, vol. 10, no. 2, 1 June 2009 (2009-06-01), pages e1684 - e1685, XP026781902, ISSN: 1567-5688, [retrieved on 20090601], DOI: 10.1016/S1567-5688(09)71632-0
- [Y] FILIP ANA-MARIA ET AL: "Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 284, no. 12, 20 March 2009 (2009-03-20), pages 7977 - 7985, XP002575465, ISSN: 0021-9258, [retrieved on 20090120], DOI: 10.1074/JBC.M808620200
- [Y] VERA PEDRO L ET AL: "Cyclophosphamide-Induced Cystitis Increases Bladder CXCR4 Expression and CXCR4-Macrophage Migration Inhibitory Factor Association", PLOS ONE, vol. 3, no. 12, December 2008 (2008-12-01), XP002699221, ISSN: 1932-6203
- See references of WO 2011038149A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2011038149 A2 20110331; WO 2011038149 A3 20111027; AU 2010298249 A1 20120419; BR 112012006468 A2 20160809; CA 2773978 A1 20110331; CN 102725311 A 20121010; EP 2480579 A2 20120801; EP 2480579 A4 20130731; IN 2423DEN2012 A 20150821; KR 20120105429 A 20120925; MX 2012003514 A 20120419
DOCDB simple family (application)
US 2010050047 W 20100923; AU 2010298249 A 20100923; BR 112012006468 A 20100923; CA 2773978 A 20100923; CN 201080052628 A 20100923; EP 10819481 A 20100923; IN 2423DEN2012 A 20120320; KR 20127010455 A 20100923; MX 2012003514 A 20100923