EP 2485730 A1 20120815 - TOPICAL FORMULATION COMPRISING ETORICOXIB AND A ZWITTERIONIC SURFACTANT
Title (en)
TOPICAL FORMULATION COMPRISING ETORICOXIB AND A ZWITTERIONIC SURFACTANT
Title (de)
TOPISCHE FORMULIERUNG MIT ETORICOXIB UND EINEM ZWITTERIONISCHEN TENSID
Title (fr)
FORMULATION TOPIQUE COMPRENANT DE L'ÉTORICOXIB ET TENSIO-ACTIF ZWITTERIONIQUE
Publication
Application
Priority
- US 25045209 P 20091009
- US 2010052111 W 20101008
Abstract (en)
[origin: WO2011044540A1] The present invention provides topical pharmaceutical compositions, methods for preparation, and methods of treatment comprising a selective COX-2 inhibitor and useful for the treatment of pain, particularly pain associated with osteoarthritis. The compositions can provide good selective COX-2 inhibitor permeability and bioavailability at the target site. In certain preferred embodiments, the invention provides a pharmaceutical composition comprising etoricoxib, a zwitterionic surfactant or charged derivative thereof, an alpha-hydroxy acid, at least one molecular penetration enhancer, at least one lower alcohol, and water.
IPC 8 full level
A61K 31/444 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2006.01); A61K 47/12 (2006.01); A61K 47/44 (2006.01); A61P 29/00 (2006.01)
CPC (source: EP)
A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 31/444 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61P 29/00 (2017.12)
Citation (search report)
See references of WO 2011044540A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
US 2010052111 W 20101008; EP 10766200 A 20101008