EP 2487186 B1 20160928 - Immunoregulatory structures from normally occuring proteins
Title (en)
Immunoregulatory structures from normally occuring proteins
Title (de)
Immunregulatorische Strukturen von normal auftretenden Proteinen
Title (fr)
Structures immunorégulatrices pour protéines naturellement produites
Publication
Application
Priority
- EP 09178421 A 20080508
- EP 08753936 A 20080508
- SE 0701099 A 20070508
- SE 0701100 A 20070508
- SE 0702520 A 20071115
Abstract (en)
[origin: WO2008136736A2] The present invention relates to isolated protein sequences that correspond to cell binding peptides, fragments, neo-structures and/or neo-epitopes of a normally occurring serum protein present in human tissue, wherein said peptide, fragment, neo-structure and/or neo- epitope has an immunoregulatory activity and is the result of either an enhanced proteolytic activity and/or conformational changes in a tissue, or a malignant tumour. In the present patent application, a common structure of several of these peptides, fragments, neo-structures and/or neo-epitopes, having immunoregulatory activity by binding to receptors on immune cells, has been identified. The present invention further also relates to monoclonal and/or polyclonal antibodies directed to a cell binding fragment of a normally occurring serum protein present in human tissue, as described above.
IPC 8 full level
C07K 14/765 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07K 16/18 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); C07K 14/765 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); G01N 33/5044 (2013.01 - US); G01N 33/57484 (2013.01 - US); A61K 38/00 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/34 (2013.01 - US); G01N 2333/55 (2013.01 - US); G01N 2333/765 (2013.01 - US); G01N 2500/10 (2013.01 - US)
Citation (examination)
- TAMURA M ET AL: "STRUCTURAL CORRELATES OF AN ANTICARCINOMA ANTIBODY: IDENTIFICATION OF SPECIFICITY-DETERMINING RESIDUES (SDRS) AND DEVELOPMENT OF A MINIMALLY IMMUNOGENIC ANTIBODY VARIANT BY RETENTION OF SDRS ONLY", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 164, no. 3, 1 February 2000 (2000-02-01), pages 1432 - 1441, XP000901556, ISSN: 0022-1767
- QIU X Q ET AL: "Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, US, vol. 25, no. 8, 1 August 2007 (2007-08-01), pages 921 - 929, XP002714946, ISSN: 1087-0156, [retrieved on 20070805]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008136736 A2 20081113; WO 2008136736 A3 20090226; WO 2008136736 A8 20090723; DK 2487186 T3 20170116; DK 3130602 T3 20191104; EP 2226334 A2 20100908; EP 2226334 A3 20101229; EP 2487186 A1 20120815; EP 2487186 B1 20160928; EP 3130602 A1 20170215; EP 3130602 B1 20190807; EP 3636667 A2 20200415; EP 3636667 A3 20200729; ES 2608803 T3 20170417; ES 2747363 T3 20200310; US 2011262470 A1 20111027; US 2016046702 A1 20160218; US 2018030126 A1 20180201; US 2020048331 A1 20200213; US 9120874 B2 20150901; US 9796777 B2 20171024
DOCDB simple family (application)
SE 2008000314 W 20080508; DK 12164229 T 20080508; DK 16189090 T 20080508; EP 09178421 A 20080508; EP 12164229 A 20080508; EP 16189090 A 20080508; EP 19190281 A 20080508; ES 12164229 T 20080508; ES 16189090 T 20080508; US 201514815471 A 20150731; US 201715667058 A 20170802; US 201916272876 A 20190211; US 59948408 A 20080508